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TranscriptomicsA function for the hnRNP A1/A2 proteins in transcription elongation
The hnRNP A1 and A2 proteins regulate processes such as alternative pre-mRNA splicing and mRNA stability. Here, we report that a reduction in the levels of hnRNP A1 and A2 by RNA interference or their cytoplasmic retention by osmotic stress drastically increases the transcription of a reporter gene....
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-67617 | biostudies-arrayexpress
ProteomicsA novel class of CLK kinases inhibitors that target SRSF10 and promote p53mediated cytotoxicity on human colorectal cancer cells
The elevated expression of the splicing regulator SRSF10 in metastatic colorectal cancer (CRC) stimulates the production of the pro-tumorigenic Bclaf1-L splice variant. We discovered a group of small molecules with an aminothiazole carboxamide core (GPS167, GPS192 and others) that decrease productio...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022333 | Pride
Clk kinases inhibitor Srsf10 Human colorectal cancer cells 
UnknownDual Targeting of EGFR and MTOR Pathways Inhibits Glioblastoma Growth by Modulating the Tumor Microenvironment.
Not available
S-EPMC9954001 | biostudies-literature
TranscriptomicsGenome-wide inter-primate comparison of gene expression profiles in multiple tissues
Regulatory changes have long been hypothesized to play an important role in primate evolution. To identify adaptive regulatory changes in humans, we performed a genome-wide survey for genes whose regulation evolves under natural selection. To do so, we used a novel multi-species microarray to measur...
ORGANISM(S): Macaca mulatta 
2008-09-17 | E-GEOD-11560 | biostudies-arrayexpress
UnknownUsing an activity tracker to increase motivation for physical activity in patients with type 2 diabetes in primary care: a randomized pilot trial.
Not available
S-EPMC8572757 | biostudies-literature
GenomicsTCERG1 regulates alternative splicing of Bcl-x gene by modulating the rate of RNAPII transcription
Complex functional coupling exists between transcriptional elongation and pre-mRNA alternative splicing. Pausing sites and changes in the rate of transcription by RNAPII may therefore have a fundamental impact in the regulation of alternative splicing. Here, we show that the elongation and splicing-...
ORGANISM(S): Homo sapiens 
2012-01-12 | E-GEOD-33716 | biostudies-arrayexpress
UnknownExperimental Partitioning of Trace Elements into Schreibersite with Applications to IIG Iron Meteorites.
Not available
S-EPMC7250238 | biostudies-literature
UnknownThe influence of heart failure high-fidelity simulation education based on NLN Jeffries simulation framework in the prelicensure nursing program: A quasi-experimental study.
Not available
S-EPMC10667501 | biostudies-literature
UnknownRethinking Borole Cycloaddition Reactivity.
Not available
S-EPMC8453799 | biostudies-literature
UnknownAn environmental data set for vector-borne disease modeling and epidemiology.
Not available
S-EPMC3995884 | biostudies-literature
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