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ProteomicsStatistical models for the analysis of isobaric Tags multiplexed quantitative proteomics
ABSTRACT: Mass spectrometry is being used to identify protein biomarkers that can facilitate development of drug treatment. Mass spectrometry based proteomics results in complex proteomic data that is hierarchical in nature often with small sample size studies. Generalized linear models (GLM) is th...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2017-07-28 | PXD005486 | Pride
Statistical models : proteomics Tmt Mixed models Biomarkers 
ProteomicsCharacterization of Citrullination Sites in Neutrophils and Mast Cells Activated by Ionomycin via Integration of Mass Spectrometry and Machine Learning
Citrullination is an important post-translational modification implicated in many diseases including rheumatoid arthritis (RA), Alzheimer's disease and cancer. Neutrophil and mast cells have different protein-arginine deiminases expression profile and ionomycin induced activation make them the ideal...
ORGANISM(S): Homo sapiens (Human) 
2022-01-12 | PXD023131 | Pride
Citrullination Mass spectrometry Mast cells Neutrophils 
ProteomicsDevelopment of a parallel reaction monitoring (PRM) mass spectrometry-assay for the detection of SARS-CoV-2 spike glycoprotein and nucleoprotein
There is an urgent need for robust and high-throughput methods for SARS-CoV-2 detection in suspected pa-tient samples to facilitate disease management, surveillance, and control. Although nucleic acid detection methods such as RT-PCR are the gold standard, during the current pandemic the deployment ...
ORGANISM(S): SARS coronavirus WHU 
2022-01-12 | PXD021080 | Pride
Skyline Nucleoprotein Qexactive hf-x Parallel reaction monitoring Sars-cov-2 Heavy standard peptides Spike protein 
ProteomicsS. aureus drives expansion of low density neutrophils in the diabetic host
Abstract S. aureus is a major opportunistic pathogen infecting patients with diabetes. Increased mortality was observed following IV S. aureus infection in diabetic mice compared to non-diabetic controls, correlating with increased numbers of low density neutrophils (LDNs) and neutrophil extracellu...
ORGANISM(S): Mus musculus (Mouse) 
2019-04-26 | PXD012176 | Pride
Ms3 Ms2 Hcd Tandem mass tags Neutrophils S.aureus 
OtherIdentifying novel targets of oncogenic EGF receptor signaling in lung cancer through global phosphoproteomics.
Data from ProteomeXchange, PXD ID: PXD001101. Experiment: pST_SILAC_R1a, file: H3255_pST_SILAC_R1_F4_a.mzml. Published as part of Proteomics. 2015 Jan;15(2-3):340-55 . From the Abstract: {{i}} . We sought to identify the immediate direct and indirect phosphorylation targets of mutant EGFRs in lung ...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320007613 | GPMDB
Resource Reanalysis 
ProteomicsComprehensive_map_HsUrine
A comprehensive map of the Human Urinary Proteome, non-glyco
ORGANISM(S): Homo Sapiens (human) 
2011-12-31 | PAe004096 | PeptideAtlas
ProteomicsQuantitative proteomic analysis of gallbladder cancer
We carried out an iTRAQ-based quantitative proteomic analysis of gallbladder cancer and adjacent non-tumor tissue to systematically identify differentially expressed proteins in gallbladder cancer. Ten gallbladder adenocarcinoma and ten adjacent non-tumor tissue samples were selected post pathologic...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000082884 | MassIVE
UnknownA multi-omic analysis of human naive CD4+ T cells.
Not available
S-EPMC4636073 | biostudies-literature
ProteomicsA Multi-Omic Analysis of Human Naive CD4 T cells
Technological advances in genomics, epigenomics, transcriptomics and proteomics have enabled massively parallel measurements across thousands of genes and gene products. Such high-throughput technologies have been extensively used to carry out genome-wide studies particularly in the context of disea...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-04-04 | MSV000079624 | MassIVE
TranscriptomicsFOXE3 Contributes to Peters Anomaly through Transcriptional Regulation of an Autophagy Associated Protein termed DNAJB1
FOXE3 is a lens specific transcription factor that has been associated with anterior segment ocular dysgenesis. To determine the transcriptional target(s) of FOXE3 that are indispensable for the anterior segment development, we examined the transcriptome and the proteome of cells expressing truncate...
ORGANISM(S): Homo sapiens 
2016-03-24 | E-GEOD-76389 | biostudies-arrayexpress
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