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TranscriptomicsGene expression profiling in neuroblastoma cells upon CHAF1A silencing
We used an inducible ShRNA system and microarrays to detail the global programme of gene expression underlying neuroblastoma differentiation upon CHAF1A silencing . CHAF1A is a subunit of the Chromatin Assembly Factor-1 (CAF1) and regulates H3K9-trimethylation. High expression of CHAF1A strongly cor...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-GEOD-51978 | biostudies-arrayexpress
GenomicsCHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming
CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming
PRJNA603348 | ENA
GenomicsSubstantial Adaptability of Mononuclear Polyploid Cardiomyocytes Revealed by Perinatal Loss of Chaf1a
Substantial Adaptability of Mononuclear Polyploid Cardiomyocytes Revealed by Perinatal Loss of Chaf1a
PRJNA1335121 | ENA
TranscriptomicsGene expression profiling in neuroblastoma cells upon CHAF1A silencing
We used an inducible ShRNA system and microarrays to detail the global programme of gene expression underlying neuroblastoma differentiation upon CHAF1A silencing . CHAF1A is a subunit of the Chromatin Assembly Factor-1 (CAF1) and regulates H3K9-trimethylation. High expression of CHAF1A strongly cor...
ORGANISM(S): Homo sapiens 
2013-11-01 | GSE51978 | GEO
ProteomicsPARP Inhibitor Sensitivity in BRCA-Proficient ovarian cancer cells is regulated by the MSH6–CHAF1A axis: 1. Chemical Proteomics
Ovarian cancer is the leading cause of gynecologic cancer-related deaths, with high-grade serous ovarian cancer (HGSOC) being the most common and lethal subtype. While BRCA1/2 mutations are established biomarkers predicting sensitivity to PARP inhibitors (PARPis), a subset of patients with BRCA-prof...
ORGANISM(S): Homo sapiens (Human) 
2026-08-21 | PXD067882 | Pride
Ovarian cancer Msh6 Parp Chaf1a 
TranscriptomicsCHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming
Neuroblastoma (NB) arises from neural crest cells (NCCs) secondary to a block in differentiation. Retinoic acid (RA) differentiation therapy has limited therapeutic efficacy, and the mechanisms preventing terminal differentiation remain elusive. We found that the chromatin modifier CHAF1A restricts ...
ORGANISM(S): Homo sapiens 
2021-07-20 | GSE144311 | GEO
UnknownCHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming.
Not available
S-EPMC8498874 | biostudies-literature
TranscriptomicsSubstantial Adaptability of Mononuclear Polyploid Cardiomyocytes Revealed by Perinatal Loss of Chaf1a
Here, we show that chromatin assembly factor 1 subunit A (Chaf1a), a key regulator of nucleosome deposition during DNA replication, is essential for postnatal cardiomyocyte proliferation and binucleation. Using cardiomyocyte-specific Chaf1a knockout mice (Myh6-Cre; Chaf1af/f), we demonstrate that Ch...
ORGANISM(S): Mus musculus 
2026-07-17 | GSE309306 | GEO
UnknownCHAF1A/B mediate silencing of unintegrated HIV-1 DNAs early in infection.
Not available
S-EPMC8795523 | biostudies-literature
UnknownCHAF1A interacts with TCF4 to promote gastric carcinogenesis via upregulation of c-MYC and CCND1 expression.
Not available
S-EPMC6306399 | biostudies-literature
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