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ProteomicsPARP Inhibitor Sensitivity in BRCA-Proficient ovarian cancer cells is regulated by the MSH6–CHAF1A axis: 1. Chemical Proteomics
Ovarian cancer is the leading cause of gynecologic cancer-related deaths, with high-grade serous ovarian cancer (HGSOC) being the most common and lethal subtype. While BRCA1/2 mutations are established biomarkers predicting sensitivity to PARP inhibitors (PARPis), a subset of patients with BRCA-prof...
ORGANISM(S): Homo sapiens (Human) 
2026-08-21 | PXD067882 | Pride
Ovarian cancer Msh6 Parp Chaf1a 
ProteomicsPARP Inhibitor Sensitivity in BRCA-Proficient ovarian cancer cells is regulated by the MSH6–CHAF1A axis: 2. ADP-Ribosylation
Ovarian cancer is the leading cause of gynecologic cancer-related deaths, with high-grade serous ovarian cancer (HGSOC) being the most common and lethal subtype. While BRCA1/2 mutations are established biomarkers predicting sensitivity to PARP inhibitors (PARPis), a subset of patients with BRCA-prof...
ORGANISM(S): Homo sapiens (Human) 
2026-08-21 | PXD067891 | Pride
Ovarian cancer Parp inhibitor Adp-ribosylation 
TranscriptomicsTranscriptional profiling of cerebral cortex and striatum from a mouse model of Huntington's disease (Q140) crossed with Msh6 heterozygous and homozygous mice
Cerebral cortex and striatum were isolated from 6-month old Msh6+/- and Msh6-/- mice crossed with the Q140 knock-in (KI) HD mice and their respective controls. Transcriptomic analysis (RNASeq) was performed on 6 genotypes: WT, Q140, Msh6+/-, Q140 X Msh6+/-, Msh6-/-, and Q140 X Msh6-/-, 8 replicates ...
ORGANISM(S): Mus musculus 
2025-02-10 | GSE271022 | GEO
GenomicsTranscriptional profiling of cerebral cortex and striatum from a mouse model of Huntington's disease (Q140) crossed with Msh6 heterozygous and homozygous mice
Transcriptional profiling of cerebral cortex and striatum from a mouse model of Huntington's disease (Q140) crossed with Msh6 heterozygous and homozygous mice
PRJNA1129435 | ENA
UnknownInteraction between the Msh2 and Msh6 nucleotide-binding sites in the Saccharomyces cerevisiae Msh2-Msh6 complex.
Not available
S-EPMC2838348 | biostudies-literature
GenomicsDYRK1A regulates B cell class switch recombination through phosphorylation of MSH6
DYRK1A regulates B cell class switch recombination through phosphorylation of MSH6
PRJNA849420 | ENA
ProteomicsDYRK1A regulates B cell class switch recombination through phosphorylation of MSH6
Effective protection from viral infections depends on the antibody-specific isotype. Here, we found that the protein kinase, DYRK1A, is essential for B cell-mediated protection from viral infection and vaccination through regulation of class switch recombination (CSR). Dyrk1a-deficient B cells were ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-16 | PXD034156 | Pride
Antibody Clonal selection B cell Class-switch recombination Humoral immunity 
UnknownBiochemical analysis of the human mismatch repair proteins hMutSα MSH2(G674A)-MSH6 and MSH2-MSH6(T1219D).
Not available
S-EPMC3323011 | biostudies-literature
UnknownSomatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern.
Not available
S-EPMC2195810 | biostudies-literature
Genomics
MSH6 sequence
PRJNA846951 | ENA
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