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TranscriptomicsSingle-cell transcriptome and T cell receptor profiling of the tuberculin skin test
We undertook single cell RNA, TCR and antibody-derived tag (ADT) sequencing of human skin suction blisters induced at the site of of the tuberculin skin test on day 2. This submission comprises data from 31 individuals (9 male, 22 female) with immunological memory to mycobacterial antigens. TotalSeq...
ORGANISM(S): Homo sapiens 
2026-07-09 | E-MTAB-14246 | biostudies-arrayexpress
UnknownPlacental telomere length shortening is not associated with severe preeclampsia but the gestational age.
Not available
S-EPMC9925682 | biostudies-literature
TranscriptomicsGene expression profiling of transmitochondrial cybrids (triple negative breast cancer cells in SUM159 background)
We used a transmitochondrial cybrid (cybrids)-based discovery approach to identify mitochondria-regulated cancer pathways in TN BCa. Cybrids were generated under a moderately metastatic TN BCa cell line SUM159 as the common nuclear background with mitochondria from benign breast epithelium (A1N4) an...
ORGANISM(S): Homo sapiens 
2016-04-14 | E-GEOD-72319 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of MDA231 cells with alterations involving beta-oxidation pathway
In order to confirm the role of fatty acid β-oxidation in Src regulation, we performed gene expression analysis in MDA231 cells from in vivo model treated with ETX or knockdown of CPT1 or CPT2 using shRNA. As expected, inhibition of β-oxidation showed a gene expression pattern that is opposite to ...
ORGANISM(S): Homo sapiens 
2016-04-14 | E-GEOD-72320 | biostudies-arrayexpress
TranscriptomicsThe bile acid CoA ligase, FATP5, is necessary for NAT synthesis in the liver
This study aimed to investigate the overlap between hepatic NAT and the bile acid synthesis to identify additional enzymes involved in NAT synthesis in the liver. We sequenced livers high-fat fed mice the were either wild-type or with a single-amino acid substitution in fatty acid amide hydrolase (F...
ORGANISM(S): Mus musculus 
2026-03-02 | E-MTAB-15752 | biostudies-arrayexpress
TranscriptomicsResponse of Rhodospirillum rubrum S1H to three pharmaceuticals
The present study explores the potential of compound-specific gene-upregulation profiles in the ubiquitous purple nonsulfur bacterium Rhodospirillum rubrum S1H as biomarkers for exposure to surface water contaminants, i.e. high production-volume pharmaceuticals. Even though the pharmaceuticals [i.e....
ORGANISM(S): Rhodospirillum rubrum 
2013-08-23 | E-GEOD-23794 | biostudies-arrayexpress
TranscriptomicsResponse of Pseudomonas aeruginosa PAO1 to low shear modeled microgravity
Anticipating the risk for infectious disease during space exploration and habitation is a critical factor to ensure safety, health and performance of the crewmembers. As a ubiquitous environmental organism that is occasionally part of the human flora, Pseudomonas aeruginosa could pose a health hazar...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2010-07-29 | E-GEOD-16970 | biostudies-arrayexpress
TranscriptomicsToxicogenomic response of Rhodospirillum rubrum S1H to the model micropollutant triclosan
Aiming at the development of a micropollutant biosensor in the frame of the Micro-Ecological Life Support System Alternative (MELiSSA), a pilot study was initiated to identify triclosan (TCS)-responsive biomarker genes in the MELiSSA carbon-mineralizing microorganism, Rhodospirillum rubrum S1H. TCS ...
ORGANISM(S): Rhodospirillum rubrum 
2010-05-19 | E-GEOD-16189 | biostudies-arrayexpress
ProteomicsLabel-free global proteome profiling of European American and African American bladder tumor patients.
Bladder cancer (BLCA) mortality is higher in African American (AA) patients compared to their European American (EA) counterparts, but the molecular mechanism underlying differences are unknown. . Thus, we performed proteomics analysis of AA and EA BLCA and identified higher mitochondrial OXPHOS spe...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-08 | MSV000095559 | MassIVE
ProteomicsMicrovesicle Proteomic profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection
High-grade ovarian cancer (HGOC) is the leading cause of mortality from gynecological malignancies, due to diagnosis at a metastatic stage. Current screening options fail to improve mortality due to the absence of early-stage-specific biomarkers. We postulated that a liquid biopsy, such as utero-tub...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-09-19 | MSV000084345 | MassIVE
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