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TranscriptomicsMRTF-SRF signaling is required for seeding of HSC/Ps in bone marrow during development
Chemokine signaling is important for the seeding of different sites by hematopoietic stem cells during development. Serum Response Factor (SRF) controls multiple genes governing adhesion and migration, mainly by recruiting members of the Myocardin-Related Transcription Factor (MRTF) family of G-acti...
ORGANISM(S): Mus musculus 
2015-03-04 | E-GEOD-63820 | biostudies-arrayexpress
TranscriptomicsPromoter hypermethylation in MLL-r leukemia: biology and therapeutic targeting
MLL-r infant acute lymphoblastic leukemia (ALL) has largely unclear oncogenesis. It has been shown unrelated to copy number change or mutations in the tyrosine kinome. We therefore, explored the possible role of genome wide CpG island hypermethylation in MLL-r infant ALL. We employed the HpaII-ti...
ORGANISM(S): Homo sapiens 
2009-12-29 | E-GEOD-19671 | biostudies-arrayexpress
TranscriptomicsGene Mapping via Bulked Segregant RNA-Seq (BSR-Seq)
Bulked segregant analysis (BSA) is an efficient method to rapidly and efficiently map genes responsible for mutant phenotypes. This procedure, however, requires access to quantitative genetic markers that are polymorphic in the mapping population. We have developed a modification of BSA (BSR-Seq) th...
ORGANISM(S): Zea mays 
2012-12-03 | E-MTAB-4234 | biostudies-arrayexpress
TranscriptomicsCHO cells with enhanced and abolished gamma-secretase activity
γ-secretase is an intra-membrane-cleaving aspartyl protease implicated in the processing of a wide range of type I membrane proteins including the Notch receptor and the amyloid-β precursor protein (APP). It thus regulates a diverse array of cellular and biological processes including the differen...
ORGANISM(S): Cricetulus griseus 
2010-05-15 | E-GEOD-16379 | biostudies-arrayexpress
TranscriptomicsThe effect of Heterogeneous Transcription Start Sites (TSS) on the Translatome: Implications for the Mammalian Cellular Phenotype.
Sequencing of total RNA and polysomal RNA of two cell lines, MCF7 (tumoral) and MCF10A (non-tumoral) Polysomal and total RNA was prepared from biological triplicates from the two cell lines. For each biological triplicate sub-confluent cell monolyers were lysed to produce cytoplasmic extracts. Half...
ORGANISM(S): Homo sapiens 
2015-11-24 | E-GEOD-74232 | biostudies-arrayexpress
TranscriptomicsMicroarray profiling of mESCs differentiation time course toward neuronal lineage
mESC adapted to 2i/LIF conditions over four passages (8 days) before differentiation towards the neuronal lineage was induced using experimental conditions described in the literature (PMID: 12524553).
ORGANISM(S): Mus musculus 
2017-09-27 | E-MTAB-5861 | biostudies-arrayexpress
Transcriptomicscelecoxib-treated vs control breast tumours
Biopsies and surgical specimens were obtained from breast tumours treated and non-treated with celecoxib 400mg twice daily for 2 weeks
ORGANISM(S): Homo sapiens 
2013-03-28 | E-MTAB-566 | biostudies-arrayexpress
TranscriptomicsMicroRNAs expression in 20(R)-ginsenoside Rg3-induced anti-angiogenesis
The angio-suppressive effect of 20(R)-ginsenoside Rg3 (Rg3-R) has been previously demonstrated, and microRNAs (miRNAs) are a vital group of small non-coding RNAs that function as post-transcriptional modulator of gene expression. Thus, using human umbilical vein endothelial cells (HUVEC) as model, w...
ORGANISM(S): Homo sapiens 
2011-09-09 | E-GEOD-31959 | biostudies-arrayexpress
TranscriptomicsRole of MicroRNA-214 in Ginsenoside-Rg1-induced Angiogenesis
MicroRNAs (miRNAs) are small non-coding RNAs that act as post-transcriptional gene modulators. Ginsenoside-Rg1, one of the active components of ginseng, has been confirmed by us as an angiogenesis inducer. Using miRNA microarray analysis, a total of 15 (including miR-214) and 3 miRNAs were found to ...
ORGANISM(S): Homo sapiens 
2010-08-05 | E-GEOD-17541 | biostudies-arrayexpress
TranscriptomicsDirect calibration of PICKY-designed microarrays
Picky is an optimal microarray design software which designed the NSF Rice 45K Array. A series of microarray experiments using a one-chip version of this array were conducted to validate as well as to develop a calibration method for Picky designed microarrays. Synthesized samples with known content...
ORGANISM(S): synthetic construct 
2010-06-21 | E-GEOD-14717 | biostudies-arrayexpress
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