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TranscriptomicsA Model System for Studying the Transcriptomic and Physiological Changes Associated with Mammalian Host-Adaptation by Leptospira interrogans Serovar Copenhageni
Leptospirosis, an emerging zoonotic disease with worldwide distribution, is caused by spirochetes belonging to the genus Leptospira. More than 500,000 cases of severe leptospirosis are reported annually, with .10% of these being fatal. Leptospires can survive for weeks in suitably moist conditions b...
ORGANISM(S): Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 
2014-03-20 | E-GEOD-53818 | biostudies-arrayexpress
TranscriptomicsReprogramming roadblocks are system-dependent
Since the first generation of induced Pluripotent Stem cells (iPSCs), several reprogramming systems have been used to study its molecular mechanisms. However, the system of choice largely affects the reprogramming efficiency, influencing our view on the mechanisms. Here we demonstrate that reprogram...
ORGANISM(S): Mus musculus 
2015-08-08 | E-GEOD-70816 | biostudies-arrayexpress
MetabolomicsMetabolomic Aspects of Conservative and Resistance-related Elements of Response to Fusarium culmorum in the Grass Family

BACKGROUND: Fusarium head blight (FHB) is a serious fungal disease of crop plants due to substantial yield reduction and production of mycotoxins in the infected grains. The breeding progress in increasing resistance with maintaining a high yield is not possible without a thoroug...

2022-10-27 | MTBLS1748 | MetaboLights
ProteomicsHuman pluripotent stem cell differentiation into hepatocyte-like cells in microfluidics: secretome and intracellular proteome.
Human pluripotent stem cells (both embryonic and induced pluripotent by reprogramming) were differentiated into hepatic-like cells inside microfluidic culture chambers and in conventional culture systems. Conditioned media and cell lysates were harvested and analyzed. Before starting the differentia...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-07-24 | MSV000084128 | MassIVE
TranscriptomicsGene expression timecourse in M-NM-^TrpaA strain
The goal of the experiment was to determine whether gene expression oscillates in the absence of rpaA. It was reported previously (e.g., Takai et al, PNAS 2006) that activity of a handful of individual expression reporters was arrythmic, and we conducted this microarray timecourse to determine whet...
ORGANISM(S): Synechococcus elongatus PCC 7942 
2013-12-04 | E-GEOD-50908 | biostudies-arrayexpress
TranscriptomicsSingle cell experiment with iPS derived neural stem cells and 28 day differentiated neuronal cells from healthy individual and NRXN1-a biallelic deletion individual
iPS cell derived neural stem cells and differentiated cells from one healthy individual and one indivudal carrying NRXN1-a biallelic deletion investigated with single cell RNA-sequencing. Celltype characterization and comparison revealed variations between stem cell identity and in cell differentiat...
ORGANISM(S): Homo sapiens 
2019-07-20 | E-MTAB-7744 | biostudies-arrayexpress
TranscriptomicsGene expression timecourse in clock rescue strains
The goal of this experiment was to determine whether global circadian gene expression oscillation depends strictly on the presence of rpaA, even when the KaiABC post-translational oscillator is oscillating with a circadian period. Strains deleted for rpaA lack functional KaiABC post-translational o...
ORGANISM(S): Synechococcus elongatus PCC 7942 
2013-12-04 | E-GEOD-50920 | biostudies-arrayexpress
TranscriptomicsChIP-on-chip with anti-RBPj antibody from embryonic AGM E11.5
Hematopoietic Stem Cells (HSC) are originated during embryonic development from endothelial-like cells located in the ventral side of the dorsal aorta around day E10-12 of murine development. This region is called AGM for Aorta/Gonad/Mesonephros refering to the tissues around the hemogenic aorta. He...
ORGANISM(S): Mus musculus 
2014-10-22 | E-GEOD-52094 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression in M-NM-^TrpaA strain and wild-type strain
The goal of the experiment was to determine the difference in gene expression between the wild-type strain and a strain lacking rpaA (M-NM-^TrpaA). Because gene expression is not at steady-state in the wild-type -- it oscillates with a circadian period -- and we did not know a priori whether it is ...
ORGANISM(S): Synechococcus elongatus PCC 7942 
2013-12-04 | E-GEOD-50919 | biostudies-arrayexpress
MetabolomicsDirect on-swab metabolic profiling of vaginal microbiome:host interactions during pregnancy and preterm birth

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) for sample preparation-free characterisation of...

2021-09-23 | MTBLS717 | MetaboLights
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