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MetabolomicsExamining the effects of cigarette smoke on mouse lens through a multi OMIC approach
Here, we report a multi OMIC (transcriptome, proteome, and metabolome) approach to investigate molecular changes in lens fiber cells (FC) of mice exposed to cigarette smoke (CS). Pregnant mice were placed in a whole-body smoke chamber and a few days later pups were born, which were exposed to CS for...
2024-03-24 | MTBLS207 | MetaboLights
TranscriptomicsExperimental identification of small non-coding RNAs in the model marine bacterium Ruegeria pomeroyi DSS-3
In oligotrophic ocean waters where bacteria are often subjected to chronic nutrient limitation, community transcriptome sequencing has pointed to the presence of highly abundant small RNAs (sRNAs). The role of sRNAs in regulating response to nutrient stress was investigated in a model heterotrophic ...
ORGANISM(S): Ruegeria pomeroyi DSS-3 
2016-02-27 | E-MTAB-4468 | biostudies-arrayexpress
UnknownMulticenter Phase IB Trial of Carboxyamidotriazole Orotate and Temozolomide for Recurrent and Newly Diagnosed Glioblastoma and Other Anaplastic Gliomas.
Not available
S-EPMC5993168 | biostudies-literature
ModelsChan2004_TCell_receptor_activation
The model reproduces Fig 3a of the paper. Please note that the authors mention that they used a value of 2 for n, n being the power in the positive feedback function for kinase autocatalysis, however the model here has n=1.95 because this results in a simulation that is identical to Fig 3a. The mode...
2024-09-02 | BIOMD0000000120 | BioModels
UnknownDetermining the frequency and level of task-sharing for hypertension management in LMICs: A systematic review and meta-analysis.
Not available
S-EPMC9035722 | biostudies-literature
TranscriptomicsExpression Data From HCMV-Infected Human Monocytes: Role of EGFR
Human cytomegalovirus (HCMV) induces pro-inflammatory monocytes following infection and we have evidence that EGFR is a key mediator in this early activation. To begin to address how this signalling pathway is responsible for the rapid activation of infected monocytes, we examined the role this pat...
ORGANISM(S): Homo sapiens 
2009-09-03 | E-GEOD-17948 | biostudies-arrayexpress
TranscriptomicsThe role of integrins in human cytomegalovirus (HCMV)-infected monocytes.
We have established that human cytomegalovirus (HCMV) infection modulates the biology of target primary blood monocytes, allowing HCMV to use monocytes as 'vehicles' for its systemic spread. HCMV infection of monocytes results in rapid induction of PI(3)K and NF-kB activity. Integrins, which are u...
ORGANISM(S): Homo sapiens 
2010-10-31 | E-GEOD-24238 | biostudies-arrayexpress
UnknownEstimated preventable COVID-19-associated deaths due to non-vaccination in the United States.
Not available
S-EPMC10123459 | biostudies-literature
ProteomicsExamining the modality-dependent target specificity of bioPROTACs by analysing global proteome changes following mRNA-encoded or recombinant protein biodegrader delivery.
Proteolysis targeting chimeras (PROTACs) have surged in popularity as a drug modality owing to their ability to degrade pathogenic proteins. Despite their advantages over conventional inhibitors, PROTAC discovery still requires high-affinity warheads, but ligands for undruggable proteins are difficu...
ORGANISM(S): Homo sapiens (Human) 
2024-06-27 | PXD049388 | Pride
Recombinant protein Proteomics Lipid nanoparticle Protac Gtpase Mass spectrometry Ras Drug delivery Bioprotac Mrna Cytosolic delivery Kras 
TranscriptomicsExpression profiles from a variety of resting and activated human immune cells
Immune cell-specific expression is one indication of the importance of a gene's role in the immune response. In order to identify such patterns, we set out to broadly profile gene expression in a variety of immune cells. We isolated twelve different types of human leukocytes from peripheral blood an...
ORGANISM(S): Homo sapiens 
2010-07-13 | E-GEOD-22886 | biostudies-arrayexpress
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