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UnknownDonepezil for Irradiated Brain Tumor Survivors: A Phase III Randomized Placebo-Controlled Clinical Trial.
Not available
S-EPMC4429174 | biostudies-literature
UnknownFactors associated with D-dimer levels in HIV-infected individuals.
Not available
S-EPMC3953205 | biostudies-literature
ProteomicsSystematic analysis of intronic microRNAs reveals cooperativity within the multi-component FTX locus to promote colon cancer development
Approximately half of all microRNAs reside within intronic regions and are often co-transcribed with their host genes. However, most studies on intronic microRNAs focus on individual microRNAs, and conversely most studies on protein-coding and non-coding genes frequently ignore any intron-derived mi...
ORGANISM(S): Homo sapiens (Human) 
2021-01-05 | PXD021823 | Pride
Micrornas A-to-i editing Colon cancer Long noncoding rna Post-transcriptional regulation 
ProteomicsLong-read transcriptome sequencing reveals abundant promoter diversity in distinct molecular subtypes of gastric cancer
Deregulated gene expression is a hallmark of cancer, however most studies to date have analyzed short-read RNA-sequencing data with inherent limitations. Here, we combine PacBio long-read isoform sequencing (Iso-Seq) and Illumina paired-end short read RNA sequencing to comprehensively survey the tra...
ORGANISM(S): Homo sapiens (Human) 
2021-02-02 | PXD023373 | Pride
Isoform sequencing (iso-seq) Alternative promoters Gastric cancer Long-read sequencing 
ProteomicsSecretory autophagy mediates mitochondria clearance in the absence of the mATG8-conjugation machinery
PINK1-Parkin mediated mitophagy, a selective form of autophagy, represents an important mechanism in mitochondrial quality control (MQC) via clearance of damaged mitochondria. Although it is well known that the conjugation of mammalian ATG8s to phosphatidylethanolamine (PE) is a key step in autophag...
ORGANISM(S): Homo sapiens (Human) 
2022-06-03 | PXD025356 | Pride
Mitochondria Autophagy 
ProteomicsA novel enzyme-mediated method for covalent surface modification of extracellular vesicles to achieve targeted drug delivery
Natural extracellular vesicles (EVs) are ideal drug carriers due to their remarkable biocompatibility. Their delivery specificity can be achieved by the conjugation of targeting ligands. However, existing methods to engineer target-specific EVs are tedious or inefficient, having to compromise betwee...
ORGANISM(S): Homo sapiens (Human) 
2021-03-24 | PXD021926 | Pride
Extracellular vesicles Rbcevs Drug delivery 
ProteomicsGlobal analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis
In addition to genomic alterations, aberrant changes in post-transcriptional regulation can modify gene function and drive cancer development. RNA-binding proteins (RBPs) are a large class of post-transcriptional regulators that have been increasingly implicated in carcinogenesis. By integrating mul...
ORGANISM(S): Homo sapiens (Human) 
2022-03-10 | PXD030215 | Pride
Post-transcriptional regulation Larp1 Myc Rna-binding protein Cancer 
UnknownAntitumor Activity of Nivolumab in Recurrent and Metastatic Nasopharyngeal Carcinoma: An International, Multicenter Study of the Mayo Clinic Phase 2 Consortium (NCI-9742).
Not available
S-EPMC5941615 | biostudies-literature
UnknownIn Rural Areas, Buprenorphine Waiver Adoption Since 2017 Driven By Nurse Practitioners And Physician Assistants.
Not available
S-EPMC6938159 | biostudies-literature
UnknownCommunity-Level Factors Associated With Racial And Ethnic Disparities In COVID-19 Rates In Massachusetts.
Not available
S-EPMC8928571 | biostudies-literature
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