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ProteomicsLabel free quantitative proteomics reveals survival mechanisms developed by Hypertrophic chondrocytes under ER stress
Emerging evidence implicates ER stress caused by unfolded mutant proteins in chondrocytes as the underlying pathology of chondrodysplasias. ER stress is triggered in hypertrophic chondrocytes (HCs) in a mouse model (13del) of metaphyseal chondrodysplasia type Schmid (MCDS) caused by misfolded mutan...
ORGANISM(S): Mus musculus (Mouse) 
2015-11-25 | PXD002125 | Pride
Metaphyseal chondrodysplasia type schmid Mitochondrial membrane polarity Glycolysis Calcium signaling 
TranscriptomicsIsoform-specific transcriptional activity of overlapping targets that respond to thyroid hormone receptors a1 and b1
Thyroid hormone receptors (TRs) are hormone-regulated transcription factors that control multiple aspects of physiology and development. TRs are expressed in vertebrates as a series of distinct isoforms that exert distinct biological roles. We wished to determine if the two most widely expressed i...
ORGANISM(S): Homo sapiens 
2009-08-08 | E-GEOD-17561 | biostudies-arrayexpress
TranscriptomicsCellodextrin utilization by Bifidobacterium breve UCC2003
The transcription of the cldEFGC gene cluster of Bifidobacterium breve UCC2003 was shown to be induced upon growth on cellodextrins, implicating these genes in the metabolism of these sugars. Phenotypic analysis of a B. breve UCC2003::cldE insertion mutant confirmed that the cld gene cluster is excl...
ORGANISM(S): Bifidobacterium breve UCC2003 
2010-08-11 | E-GEOD-17604 | biostudies-arrayexpress
ProteomicsER stress and dsRNA sensing with Rt3D and palbociclib - Immunopeptidome
Cytoplasmic pattern recognition receptors (PRRs) for double-stranded RNA (RIG-I/MDA5) are key mediators of anti-viral responses. PRR agonists, such as dsRNA oncolytic Reovirus type 3 Dearing (Rt3D), potently activate RNA sensors. We used an unbiased cytotoxicity screen to reveal synergistic drug-vir...
ORGANISM(S): Homo sapiens (Human) 
2025-05-02 | PXD036559 | Pride
A375 Tmtpro Immunopeptidome 
UnknownHER2-enriched subtype and novel molecular subgroups drive aromatase inhibitor resistance and an increased risk of relapse in early ER+/HER2+ breast cancer.
Not available
S-EPMC9482930 | biostudies-literature
ProteomicsER stress and dsRNA sensing with Rt3D and palbociclib - Whole Proteome
Cytoplasmic pattern recognition receptors (PRRs) for double-stranded RNA (RIG-I/MDA5) are key mediators of anti-viral responses. PRR agonists, such as dsRNA oncolytic Reovirus type 3 Dearing (Rt3D), potently activate RNA sensors. We used an unbiased cytotoxicity screen to reveal synergistic drug-vir...
ORGANISM(S): Homo sapiens (Human) 
2025-05-02 | PXD036540 | Pride
Human A375 Proteome Tmt 
UnknownPI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression.
Not available
S-EPMC6503687 | biostudies-literature
TranscriptomicsMetabolism of four α-glycosidic linkage-containing oligosaccharides by Bifidobacterium breve UCC2003
Members of the genus Bifidobacterium are common inhabitants of the gastrointestinal tract of humans and other mammals, where they ferment many diet-derived carbohydrates that cannot be digested by their host. To extend our understanding of bifidobacterial carbohydrate utilisation, we investigated th...
ORGANISM(S): Bifidobacterium breve 
2013-08-16 | E-GEOD-47448 | biostudies-arrayexpress
TranscriptomicsRibose utilization by the human commensal Bifidobacterium breve UCC2003
Growth of B. breve UCC2003 on ribose leads to the transcriptional induction of the rbsACBDK gene cluster. Generation and phenotypic analysis of an rbsA insertion mutant established that the rbs gene cluster is essential for ribose utilization, and that its transcription is likely regulated by a LacI...
ORGANISM(S): Bifidobacterium breve UCC2003 
2010-05-19 | E-GEOD-17325 | biostudies-arrayexpress
TranscriptomicsSmall RNA mediated immune responses: insights from analyses of nine soybean R-gene near-isogenic lines and their susceptible parent
Small RNAs, including microRNAs (miRNAs) and small interfering RNAs (siRNAs) are negative regulators to target endogenous genes and repetitive sequences in plants. Although miRNAs and trans-acting or phased siRNAs (tasiRNAs or phasiRNAs) were found to target hundreds of disease related genes in Medi...
ORGANISM(S): Glycine max 
2015-04-15 | E-GEOD-56859 | biostudies-arrayexpress
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