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GenomicsMouse ooplasm confers context-specific reprogramming capacity
Enucleated oocytes have the remarkable ability to reprogram somatic nuclei back to totipotency. Here we investigate genome-scale DNA methylation patterns after nuclear transfer and identify specific targets for DNA demethylation as well as NT specific limitations. We find that the ooplasm can confer...
ORGANISM(S): Mus musculus 
2012-08-10 | E-GEOD-38711 | biostudies-arrayexpress
GenomicsDNA methylation dynamics of the human pre-implantation embryo
We present genome-scale maps of DNA methylation in early human development and perform comparative analysis to mouse that confirm a conserved global erasure of the paternal genome. We find that while many global features of the early embryo are consistent between the two species, the target sequenc...
ORGANISM(S): Mus musculus 
2014-07-23 | E-GEOD-51239 | biostudies-arrayexpress
UnknownDonepezil for Irradiated Brain Tumor Survivors: A Phase III Randomized Placebo-Controlled Clinical Trial.
Not available
S-EPMC4429174 | biostudies-literature
GenomicsA unique regulatory phase of DNA methylation in the early mammalian embryo
DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly accepted that the paternal genome is actively depleted of global cytosine methylation at fertilization, followed by passive depletion that reaches a minimum at the blastocyst stage. However, this model is based on limit...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-34864 | biostudies-arrayexpress
ProteomicsDetection SARS-CoV-2 infection in mice by ATR-FTIR
Vero-E6 cell supernatant, mice lavage and human saliva were evaulated after exposure to SARS-CoV-2 via ATR-FTIR spectoscopy. To provide further information about the physiological response, proteins contained in the mouse lavage were assessed via shotgun proteomics (data shown here). Mice were expos...
ORGANISM(S): Homo sapiens (Human) 
2021-12-17 | PXD030012 | Pride
Sars-cov-2 Ftir Covid-19 
UnknownTreatment Efficacy, Adherence, and Quality of Life Among Women Younger Than 35 Years in the International Breast Cancer Study Group TEXT and SOFT Adjuvant Endocrine Therapy Trials.
Not available
S-EPMC5597253 | biostudies-literature
Genomics3a29872b-a736-415c-b42b-d2ee95d79c54 - samples
WGS with linked reads of pediatric glioblastoma. For each patient, blood and tumor tissue were sequenced. For two patients, we also provide sequencing data for the blood of their parents.
EGAD00001005212 | EGA
GenomicsWhole genome sequencing with linked reads of pediatric glioblastoma samples
Pediatric glioblastoma (pGBM) is a lethal cancer with no effective therapies. To understand mechanisms of tumor evolution in this cancer, we performed whole genome sequencing with linked reads on longitudinally resected pGBM samples. Our analyses showed that all diagnostic and recurrent samples were...
EGAS00001003432 | EGA
GenomicsCharbonneau Cancer Institute DAC
Data Access Committee EGAC00001001280
EGAC00001001280 | EGA
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