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ProteomicsWhat does next generation Mass Spectrometry offer for proteomics? A comprehensive platform comparison
Next-generation mass spectrometry platforms (Orbitrap Astral, timsTOF Ultra) are reshaping proteomics by enhancing analytical depth and sensitivity. We compared these platforms against Orbitrap Exploris 480 using neonatal mouse lung tissue from a bronchopulmonary dysplasia model (n=12), employing fo...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-02 | PXD057442 | Pride
Mouse Lung Bronchopulmonary dysplasia Platform comparison 
ProteomicsProteomics of Skin Proteins in Psoriasis
Herein we demonstrate the efficacy of an unbiased proteomics screening approach for studying protein expression changes in the KC-Tie2 psoriasis mouse model, identifying multiple protein expression changes in the mouse and validating these changes in human psoriasis. KC-Tie2 mouse skin samples (n=3...
ORGANISM(S): Mus musculus (Mouse) 
2014-10-30 | PXD001387 | Pride
Psoriasis Trangenic mouse Lc-msms 
ProteomicsPhosphoproteomics Profiling of Non-Small Cell Lung Cancer Cells Treated with a Novel Phosphatase Activator
Activation of protein phosphatase 2A (PP2A) is a promising anti-cancer therapeutic strategy given this tumor suppressor’s ability to coordinately downregulate multiple pathways involved with growth and proliferation.Here, we studied the global signaling response signature of a novel small molecule a...
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD005698 | Pride
Non-small cell lung cancer Phosphatase activation Signaling response signatures Functional network analysis Label-free phosphoproteomics 
ProteomicsTemporal and sex-linked protein expression dynamics in a familial model of Alzheimer’s Disease
Mouse models of Alzheimer’s Disease (AD), which show progression through various AD stages reflective of human pathology, like 5XFAD, are well established tools for uncovering novel AD related pathways. In addition, they permit temporal examination of the intermingling of AD related pathways and can...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-16 | PXD030161 | Pride
Hippocampus Alzheimer’s disease Brain Neurodegenerative diseases Temporal Mice 5xfad 
UnknownSignal detection theory applied to giant pandas: Do pandas go out of their way to make sure their scent marks are found?
Not available
S-EPMC10495809 | biostudies-literature
UnknownDisrupted rich club network in behavioral variant frontotemporal dementia and early-onset Alzheimer's disease.
Not available
S-EPMC4883024 | biostudies-literature
TranscriptomicsLarge scale variation in copy number in chicken breeds
Background: Detecting genetic variation is a critical step in elucidating the molecular mechanisms underlying phenotypic diversity. Until recently, such detection has mostly focused on single nucleotide polymorphisms (SNPs) because of the ease in screening complete genomes. Another type of variant, ...
ORGANISM(S): Gallus gallus 
2013-08-21 | E-GEOD-47623 | biostudies-arrayexpress
UnknownRich club analysis in the Alzheimer's disease connectome reveals a relatively undisturbed structural core network.
Not available
S-EPMC4504816 | biostudies-literature
UnknownKuru prions and sporadic Creutzfeldt-Jakob disease prions have equivalent transmission properties in transgenic and wild-type mice.
Not available
S-EPMC2268835 | biostudies-literature
UnknownEpigenetic modifications are associated with inter-species gene expression variation in primates.
Not available
S-EPMC4290387 | biostudies-literature
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