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ProteomicsDRT1 FLAG Pulldown Raw Data from Exploris 480
We aim to see what T4 phage and/or E. coli proteins interact with our DRT1 enzyme. We have conducted a pulldown assay using N-terminally MBP-tagged DRT1, both for WT and RT-inactive mutant.
ORGANISM(S): Escherichia Coli 
2026-07-10 | PXD070039 | JPOST Repository
GenomicsNKX3-1, a Novel Transcriptional Factor of AR, Promotes Prostate Cancer Cell Survival via RAB3B GTPase-mediated protein trafficking
Androgen receptor (AR) orchestrates an intricate transcriptional regulatory network that governs prostate cancer initiation, development and progression. To understand this network in detail, we generated genome-wide maps of AR occupancy by ChIP-seq in LNCaP cells. We found NKX3-1, an androgen-depen...
ORGANISM(S): Homo sapiens 
2011-11-16 | E-GEOD-28264 | biostudies-arrayexpress
GenomicsTMPRSS2-ERG, HDACs and EZH2 are involved in an AR-centric transcriptional circuitry that calibrates androgenic response for prostate cancer progression (ChIP-Seq data)
Deregulation of the Androgen Receptor (AR) transcriptional network is a common hallmark in prostate cancers. To achieve its precise transcriptional role, AR needs to co-operate specifically with a plethora of cofactors. In prostate cancers, AR transcription collaborators are frequently aberrantly ov...
ORGANISM(S): Homo sapiens 
2012-04-26 | E-GEOD-28950 | biostudies-arrayexpress
TranscriptomicsTMPRSS2-ERG, HDACs and EZH2 are involved in an AR-centric transcriptional circuitry that calibrates androgenic response for prostate cancer progression (gene expression data)
Deregulation of the Androgen Receptor (AR) transcriptional network is a common hallmark in prostate cancers. To achieve its precise transcriptional role, AR needs to co-operate specifically with a plethora of cofactors. In prostate cancers, AR transcription collaborators are frequently aberrantly ov...
ORGANISM(S): Homo sapiens 
2012-04-26 | E-GEOD-28948 | biostudies-arrayexpress
UnknownLymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice.
Not available
S-EPMC6002772 | biostudies-literature
GenomicsATAC-seq of Oesophageal Cell Lines
ATAC-seq in oesophageal cell lines, OE33 (OAC), FLO1 (OAC), HET1A (Normal)
ORGANISM(S): Homo sapiens 
2016-09-12 | E-MTAB-4209 | biostudies-arrayexpress
GenomicsTissue-type specific estrogen signaling in breast and uterine cancer cells
Estrogen receptors play critical roles in both the normal physiological, and disease states of numerous tissues, including breast and uterus. Estrogen receptor alpha (ER) can activate or repress the expression of target genes upon estrogen stimulation. In order to better understand the transcription...
ORGANISM(S): Homo sapiens 
2011-01-05 | E-GEOD-23893 | biostudies-arrayexpress
UnknownA role for CXCL13 (BCA-1) in pregnancy and intra-amniotic infection/inflammation.
Not available
S-EPMC3169890 | biostudies-literature
GenomicsCENTDIST: Discovery of Co-associated Factors by Motif Distribution
Transcription factors (TFs) do not function alone but work together with other TFs (called co-TFs) in a combinatorial fashion to precisely control the transcription of target genes. Mining co-TFs is thus important to understand the mechanism of transcriptional regulation. Although existing methods c...
ORGANISM(S): Homo sapiens 
2012-04-25 | E-GEOD-28857 | biostudies-arrayexpress
TranscriptomicsActivator protein-2γ is a critical determinant of estrogen receptor interactome formation and gene transcription in breast cancer [expression]
Estrogen receptor α (ERα) is key player in the progression of breast cancer. ERα binds to DNA and mediates long-range chromatin interactions throughout the genome, but the underlying mechanism in this process is unclear. Here, we show that AP-2 motifs are highly enriched in the ERα binding sites...
ORGANISM(S): Homo sapiens 
2011-06-02 | E-GEOD-26740 | biostudies-arrayexpress
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