Sort   by:  
 Page size 
MetabolomicsDysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

Streptococcus pneumoniae is the primary cause of community-acquired bacterial pneumonia with rates of penicillin and multi-drug resistance exceeding 80% and 40%, respectively. The innate immune response generates a variety of antimicrobial agents to control infection including zinc stres...

2022-02-23 | MTBLS318 | MetaboLights
MetabolomicsXMulti-omics reveals zearalenone-induced hepato-intestinal injury and growth dysregulation in largemouth bass (Micropterus salmoides)
Zearalenone (ZEN), a prevalent Fusarium-derived mycotoxin in plant protein-based aquafeeds, poses severe threats to farmed aquatic animals. However, its toxic effects and underlying mechanisms on the commercially critical largemouth bass (Micropterus salmoides) remain largely uncharacterized. Here, ...
2026-05-05 | MTBLS14430 | MetaboLights
ProteomicsKCNK3 channel dysregulation in PAH
Introduction. Pulmonary arterial hypertension (PAH) is a severe cardiopulmonary disease that may be triggered by exposure to drugs such as dasatinib or facilitated by genetic predispositions. The incidence of dasatinib-associated PAH is estimated at 0.45%, suggesting individual predispositions. The ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-17 | PXD042425 | Pride
Apex Channel dysregulation Turboid Kcnk3 
UnknownAltered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1.
Not available
S-EPMC7689299 | biostudies-literature
UnknownPreventing unfolded protein response-induced ion channel dysregulation to treat arrhythmias.
Not available
S-EPMC9149111 | biostudies-literature
UnknownCalcineurin Dysregulation Underlies Spinal Cord Injury-Induced K+ Channel Dysfunction in DRG Neurons.
Not available
S-EPMC5566871 | biostudies-literature
TranscriptomicsTMEM41B is an endoplasmic reticulum Ca2+ release channel maintaining naive T cell quiescence and responsiveness
In mammalian cells, endoplasmic reticulum (ER) passively releases Ca2+ under steady state, but channels involved remain elusive. Here, we report that TMEM41B, an ER-resident membrane protein critical for autophagy, lipid metabolism, and viral infection, functions as an ER Ca2+ release channel. Bioch...
ORGANISM(S): Mus musculus 
2025-03-01 | GSE285373 | GEO
GenomicsMild neonatal hypoxia targets synaptic maturation, disrupts adult hippocampal learning and memory and is associated with CK2-mediated dysregulation of synaptic calcium-activated potassium channel KCNN2
Mild neonatal hypoxia targets synaptic maturation, disrupts adult hippocampal learning and memory and is associated with CK2-mediated dysregulation of synaptic calcium-activated potassium channel KCNN2
PRJNA1309636 | ENA
TranscriptomicsGenome-wide mRNA expression analyses revealed dysregulation of genes important for SAN function in Hcn4-CreERT2;Isl1 mutants.
Understanding factors that drive development and function of the sinoatrial node (SAN) is crucial to development of potential therapies for sinus arrhythmias, including potential generation of biological pacemakers. Here, we identify a key cell autonomous role for the LIM homeodomain transcription f...
ORGANISM(S): Mus musculus 
2015-07-24 | E-GEOD-69097 | biostudies-arrayexpress
GenomicsTMEM41B is an endoplasmic reticulum Ca2+ release channel maintaining naive T cell quiescence and responsiveness
TMEM41B is an endoplasmic reticulum Ca2+ release channel maintaining naive T cell quiescence and responsiveness
PRJNA1203242 | ENA
Sort   by:  
 Page size