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ProteomicsA chaperone-assisted mechanism of outer mitochondrial membrane TOM70 insertion protective against diet-induced obesity
Outer mitochondrial membrane (OMM) proteins communicate with the cytosol and other organelles including the endoplasmic reticulum (ER). This communication is important in thermogenic adipocytes to increase energy expenditure that controls body temperature and weight. However, the regulatory mechanis...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-02 | PXD055263 | Pride
Mitochondria Tom70 Chaparone Obesity 
ProteomicsA chaperone-assisted mechanism of outer mitochondrial membrane TOM70 insertion protective against diet-induced obesity
Outer mitochondrial membrane (OMM) proteins communicate with the cytosol and other organelles including the endoplasmic reticulum (ER). This communication is important in thermogenic adipocytes to increase energy expenditure that controls body temperature and weight. However, the regulatory mechanis...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-02 | PXD054182 | Pride
Obesity Mitochondria Ppid Tom70 Perk Mitochondrial transport Chaparone 
ProteomicsStructural basis of respiratory complexes adaptation to cold temperatures
In response to cold, mammals activate brown fat for respiratory-dependent thermogenesis reliant on the electron transport chain. Yet, the structural basis of respiratory complex adaptation to cold remains elusive. Herein we combined thermoregulatory physiology and cryo-EM to study endogenous respira...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-02 | PXD054042 | Pride
Obesity Mitochondria Ppid Tom70 Perk Mitochondrial transport Chaparone 
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