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ProteomicsA chaperone-assisted mechanism of outer mitochondrial membrane TOM70 insertion protective against diet-induced obesity
Outer mitochondrial membrane (OMM) proteins communicate with the cytosol and other organelles including the endoplasmic reticulum (ER). This communication is important in thermogenic adipocytes to increase energy expenditure that controls body temperature and weight. However, the regulatory mechanis...
ORGANISM(S): Homo sapiens (Human) 
2024-10-03 | PXD053607 | Pride
Xlms Tom70 Clms Crosslinking 
ProteomicsA chaperone-assisted mechanism of outer mitochondrial membrane TOM70 insertion protective against diet-induced obesity
Outer mitochondrial membrane (OMM) proteins communicate with the cytosol and other organelles including the endoplasmic reticulum (ER). This communication is important in thermogenic adipocytes to increase energy expenditure that controls body temperature and weight. However, the regulatory mechanis...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-02 | PXD055263 | Pride
Mitochondria Tom70 Chaparone Obesity 
ProteomicsA chaperone-assisted mechanism of outer mitochondrial membrane TOM70 insertion protective against diet-induced obesity
Outer mitochondrial membrane (OMM) proteins communicate with the cytosol and other organelles including the endoplasmic reticulum (ER). This communication is important in thermogenic adipocytes to increase energy expenditure that controls body temperature and weight. However, the regulatory mechanis...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-02 | PXD054182 | Pride
Obesity Mitochondria Ppid Tom70 Perk Mitochondrial transport Chaparone 
ProteomicsThe mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress
Most mitochondrial proteins are synthesized as precursor proteins in the cytosol and post-translationally transported into mitochondria. The mitochondrial surface protein Tom70 acts at the interface of the cytosol and mitochondria. In vitro import experiments identified Tom70 as targeting receptor, ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-03-29 | PXD021173 | Pride
Chaperones  mitochondria  outer membrane  proteostasis  tom70 
UnknownTom70-based transcriptional regulation of mitochondrial biogenesis and aging.
Not available
S-EPMC8926401 | biostudies-literature
UnknownHuman mitochondrial import receptor Tom70 functions as a monomer.
Not available
S-EPMC5026490 | biostudies-literature
ProteomicsHEK293 WT and TOM70 KD cell lines expressing HA-tagged Orf9b grown on glucose media
Comparison of whole cell proteome of HEK293 WT and TOM70 KD cell lines expressing HA-tagged Orf9b grown on glucose media.
ORGANISM(S): Homo sapiens (Human) 
2023-08-30 | PXD040491 | Pride
Orf9b Tom70 Glucose 
ProteomicsHEK293 WT and TOM70 KD cell lines expressing HA-tagged Orf9b grown on galactose media
Comparison of whole cell proteome of HEK293 WT and TOM70 KD cell lines expressing HA-tagged Orf9b grown on galactose media
ORGANISM(S): Homo sapiens (Human) 
2023-08-30 | PXD040494 | Pride
Orf9b Tom70 Galactose 
UnknownTom70 serves as a molecular switch to determine pathological cardiac hypertrophy.
Not available
S-EPMC4123302 | biostudies-literature
UnknownTetratricopeptide repeat proteins Tom70 and Tom71 mediate yeast mitochondrial morphogenesis.
Not available
S-EPMC2246612 | biostudies-literature
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