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ProteomicsIntegrated multi-omic analysis of M. tuberculosis H37Ra redefines virulence attributes
M. tuberculosis H37Ra, an avirulent tubercle bacillus, is a commonly used model to investigate virulence attenuation in M. tuberculosis. Comparative high-throughput studies have earlier correlated its avirulence to the presence of specific mutations or absence of certain proteins. However, a recent ...
ORGANISM(S): Mycobacterium tuberculosis H37Ra 
2018-10-22 | PXD008555 | Pride
Genome annotation Tuberculosis Virulence attenuation Orbitrap Next-generation sequencing 
MetabolomicsOn-line untargeted metabolomics monitoring of an Escherichia coli succinate fermentation process
The real-time monitoring of metabolites (RTMet) is instrumental for the industrial production of biobased fermentation products. This study shows the first application of untargeted on-line metabolomics for the monitoring of undiluted fermentation broth samples taken automatically from a 5 L bioreac...
2023-04-26 | MTBLS5197 | MetaboLights
UnknownSite-specific radical formation in DNA induced by Cu(II)-H₂O₂ oxidizing system, using ESR, immuno-spin trapping, LC-MS, and MS/MS.
Not available
S-EPMC3100166 | biostudies-literature
TranscriptomicsCryptochrome 1 regulates growth and development in Brassica through alteration in the expression of genes involved in light, phytohormone and stress signalling.
To cover a comprehensive understanding of the complex regulatory networks controlling cryptochrome 1(CRY1)-mediated photomorphogenic response in Brassica, a genome-wide differential expression analysis was performed for the 5-day-old T3 BnCRY1-OE and wild type seedlings grown under white light (100 ...
ORGANISM(S): Brassica juncea 
2014-01-10 | E-GEOD-26797 | biostudies-arrayexpress
ProteomicsSynaptic protein S-palmitoylation as a novel mechanism underlying sex-dependent differences in neuronal plasticity
Although sex differences in the brain are prevalent, the knowledge about mechanisms underlying sex-related effects on normal and pathological brain functioning is rather poor. It is known that female and male brains differ in size and connectivity. Moreover, those differences are related to neuronal...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-23 | PXD025286 | Pride
Sex-dependent Dhhc7 Palmitoylation 
ProteomicsSaLT&PepPr is an Interface-Predicting Language Model for Designing Peptide-Guided Protein Degraders
Cell lysates were adjusted to 5% SDS, and 20 ugs was reduced with 10 mM DTT and alkylated with 25 mM iodoacetamide followed by digestion with 1:15 trypsin using an S-trap at 47 degC for 1 h. Lyophilized peptides were reconstituted at 0.5 ugs/uL, and a study pool QC sample was made by mixing equal vo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-12 | MSV000093088 | MassIVE
ProteomicsChronic shisha exposure alters phosphoproteome of oral keratinocytes
Shisha smoking has been epidemiologically linked to development of oral lesions as well as various cancers. However, few molecular studies investigate the pathobiology of shisha induced cancer. In this study we investigate the effects of chronic shisha exposure in an in vitro model using normal, imm...
ORGANISM(S): Homo sapiens (Human) 
2019-07-23 | PXD011318 | Pride
Oral cancer Hookah Waterpipe tobacco smoking Narghile tobacco Carcinogenesis High-throughput Oscc Orbitrap fusion 
ProteomicsIdentification of potential biomarkers of head and neck squamous cell carcinoma using iTRAQ based quantitative proteomic approach
Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers in India. Despite improvements in treatment strategy, the survival rates of HNSCC patients remains poor. Thus, it is necessary to identify biomarkers that can be used for early detection of disease. In this study, we emp...
ORGANISM(S): Homo sapiens (Human) 
2018-09-19 | PXD009241 | Pride
Mass spectrometry Hnscc Parallel reaction monitoring Itraq Okf6/tert 
TranscriptomicsExpression Profiling of Inflammatory Breast Cancer Cells Treated with the Novel Histone Deacetylase Inhibitor, CG-1521
Studies of gene expression profiles using the whole genome wide microarray analysis in SUM149PT cells (ER-, p53mut) and SUM190PT cells (ER-, p53mut) when treated with 5 or 7.5 uM CG-1521 alone and in combination with 10 nM 17beta-estradiol. Comparisons between each treatment group provides evidence ...
ORGANISM(S): Homo sapiens 
2011-04-12 | E-GEOD-28542 | biostudies-arrayexpress
ProteomicsProteomic analysis of oral keratinocytes chronically exposed to shisha
Shisha smoking is widely believed to be a hazard-free habit. Studies have reported shisha smoking to be associated with oral lesions as well ascarcinomas of the lung, esophagus, bladder, and pancreas. A better understanding of the underlying mechanism may contribute to the identification of biomarke...
ORGANISM(S): Homo sapiens (Human) 
2019-02-21 | PXD011106 | Pride
Immune response Interferon pathway Proteomics Oxidative stress In vitro cellular model 
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