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MetabolomicsThe Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism
The overuse of antibiotics in animal agriculture and medicine has caused a series of potential threats to public health. Macleaya cordata is a medicinal plant species from the Papaveraceae family, providing a safe resource for the manufacture of antimicrobial feed additive for livestock. The active ...
2017-04-24 | MTBLS435 | MetaboLights
ProteomicsAATF interactome in human Kms27 cells
Multiple myeloma is a hematological neoplasm of plasma cells characterized by an abnormal production of immunoglobulins. Che-1/AATF (Che-1) is an RNA binding protein involved in transcription regulation and highly expressed in this malignancy. In order to better characterize its functions in this ty...
ORGANISM(S): Homo sapiens (Human) 
2022-08-03 | PXD026659 | Pride
Multiple myeloma Aatf 
GenomicsH3K4me3 modification analysis comparing Lsh WT and Lsh-/- MEFs
DNA methylation is critical for normal development and plays important roles in genome organization and transcriptional regulation. Although DNA methyltransferases have been identified, the factors that establish and contribute to genome-wide methylation patterns remain elusive. Here, we report a hi...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-29393 | biostudies-arrayexpress
TranscriptomicsInnate and adaptive immunity in zebrafish: time course (zebrafish)
The interaction between fungal pathogen and host innnate and adaptive immunity during infection is a complex and dynamic process. To resolve this, we chose the zebrafish model organism as the host to study C. albicans infection via systems biology approach. Transcriptome microarray data and histolog...
ORGANISM(S): Danio rerio 
2014-11-03 | E-GEOD-51603 | biostudies-arrayexpress
ProteomicsProteomics Data of "Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema" Study
Background: Chronic hand eczema (CHE) is a debilitating skin condition characterized by pain, itch, and chronic inflammation, with a complex multifactorial origin. Its diverse presentations, including overlapping traits of atopic dermatitis, contact dermatitis, and psoriasis, make diagnosis and trea...
ORGANISM(S): Homo sapiens (Human) 
2026-02-26 | PXD059218 | Pride
TranscriptomicsIdentification of WRKY22 direct targets under submergence in Arabidopsis with ChIP
To identify direct targets of WRKY22, we created a transgenic Arabidopsis line that expresses a c-myc epitope-tagged WRKY22 and used ChIP followed by microarray hybridization (ChIP-chip) to screen for candidates and validate the in vivo protein-DNA interactions with ChIP followed by quantitative PCR...
ORGANISM(S): Arabidopsis thaliana 
2013-07-03 | E-GEOD-40138 | biostudies-arrayexpress
UnknownPhosphorescent [3 + 2 + 1] coordinated Ir(iii) cyano complexes for achieving efficient phosphors and their application in OLED devices.
Not available
S-EPMC8336439 | biostudies-literature
TranscriptomicsExpression data from naM-CM-/ve and MPTP-exposed cholinergic transgenic mice
PD is the second most common neurodegenerative disease worldwide with growing prevalence. MPTP is a neurotoxin which causes the appearance of Parkinson's disease (PD) pathology. The involvement of the cholinergic system in PD has been identified decades ago and anti-cholinergic drugs were upon the...
ORGANISM(S): Mus musculus 
2012-01-09 | E-GEOD-31458 | biostudies-arrayexpress
TranscriptomicsmiR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling.
miR-222 overexpression leads to promotion of proliferation and hypertrophy and inhibition of apoptosis in in primary neonatal rat ventricular cardiomyocytes (NRVMs). Isolated primary neonatal rat ventricular cardiomyocytes were plated in 6 cm BD Primaria tissue culture dishes. Transfection of microR...
ORGANISM(S): Rattus norvegicus 
2016-03-03 | E-GEOD-59641 | biostudies-arrayexpress
ProteomicsAn Anti-Cancer Gold(III)-Activated Porphyrin Scaffold that Covalently Modifies Protein Cysteine Thiols
Cysteine thiols of many cancer-associated proteins are attractive targets of anti-cancer agents. Herein, we unequivocally demonstrate a distinct thiol-targeting property of gold(III) mesoporphyrin IX dimethyl ester (AuMesoIX) and its anti-cancer activities. While the binding of cysteine thiols with ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD016875 | Pride
Gold • porphyrin • ligand reactivity• cysteine thiol conjugation • anti-tumor agents 
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