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TranscriptomicsTranscriptional analysis of kidney infiltrating T cells after ischemia reperfusion injury reveals a pathophysiologic role for the chemokine (C-C motif) receptor 5
We examined the transcriptional responses in kidney infiltrating T cells 6 hrs after IRI CD3 (+) T cells were purified applying magnetic beads to mononuclear cells extracted from kidney by percoll gradient methods. The total T-cell RNA was isolated, and trabscript abundance measured with array-based...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-23747 | biostudies-arrayexpress
UnknownTime-dependent c-Myc transactomes mapped by Array-based nuclear run-on reveal transcriptional modules in human B cells.
Not available
S-EPMC2837740 | biostudies-literature
TranscriptomicsAlternate protein kinase A activity identifies a unique population of stromal cells in adult bone
We investigated the Prkar1a+/- mice when bred with Prkaca+/- genetic backgrounds. Prkar1a+/-Prkaca+/- mice not only continued to develop bone lesions but also demonstrated a significant increase in both the number and the severity of the lesions, as well as a reduction in the age of first appearance...
ORGANISM(S): Mus musculus 
2010-03-21 | E-GEOD-20984 | biostudies-arrayexpress
TranscriptomicsACTH-independent macronodular adrenocortical hyperplasia (AIMAH)
ACTH-independent macronodular adrenal hyperplasia (AIMAH) is a clinically and genetically heterogeneous disorder that can be associated with aberrant hormone receptors. Whole-genome expression profiling was analyzed in samples of different nodules from a patient with AIMAH. Total RNA obtained from a...
ORGANISM(S): Homo sapiens 
2010-10-30 | E-GEOD-25031 | biostudies-arrayexpress
TranscriptomicsActivation of cyclic AMP signaling leads to different pathway alterations in lesions of the adrenal cortex caused by germline PRKAR1A defects versus those due to somatic GNAS mutations
PRKAR1A inactivating mutations are responsible for primary pigmented nodular adrenocortical disease (PPNAD) whereas somatic GNAS activating mutations cause macronodular disease in the context of McCune-Albright syndrome (MAS), ACTH-independent hyperplasia (AIMAH) and, rarely, cortisol-producing aden...
ORGANISM(S): Homo sapiens 
2011-11-15 | E-GEOD-33694 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of normal and tumor-like bone cells from neonatal-onset multisystem inflammatory disease (NOMID)
We analyzed the whole transcriptome profiling of NOMID normal and tumor-like bone cells Total RNA obtained from NOMID bone tumor culture was compared to NOMID normal cartilage cells established from the same patient.
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-21835 | biostudies-arrayexpress
TranscriptomicsRIP-chip analysis of Tino/hMEX-3D mRNPs
Tino is an A+U-Rich Element (ARE) binding protein first identified through its ability to bind to bcl-2 mRNA and to contribute to its degradation. It has recently been recognized as a shorter form of the human Mex-3D protein (hMex-3D), one of the four members of the family of Mex-3 RNA-binding phosp...
ORGANISM(S): Homo sapiens 
2010-02-28 | E-GEOD-12239 | biostudies-arrayexpress
TranscriptomicsDefining precision probes which differentiate between the activity of type I and type II interferons.
To define probes which differentiate between the activity of type I or type II IFN, a human submandibular gland (HSG) cell line was cultured for 48 hours in the absence or presence of IFNa or IFNg. Gene expression was assayed at 4, 12, 24 or 48 hours and was compared to gene expression in untreated ...
ORGANISM(S): Homo sapiens 
2012-10-08 | E-GEOD-41291 | biostudies-arrayexpress
UnknownAcute liver effects, disposition and metabolic fate of [14C]-fenclozic acid following oral administration to normal and bile-cannulated male C57BL/6J mice.
Not available
S-EPMC5489613 | biostudies-literature
GenomicsCaenorhabditis elegans
Extension of lifespan in C. elegans by naphthoquinones that act through stress hormesis mechanisms
PRJNA139489 | ENA
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