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UnknownTargeted Regulation of HSP70 by the ARP2/3 Complex in Mammary Epithelial Cells and Its Impact on Host Cell Apoptosis.
Mastitis is frequently triggered by the bacterial disruption of the epithelial cell barrier. The actin-related protein 2/3 complex (Arp2/3), a major endogenous protein involved in cytoskeletal regulation, plays a crucial role in preserving epithelial barrier integrity during inflammation; however, i...
S-EPMC12025207 | biostudies-literature
UnknownPrediagnostic Plasma 25-Hydroxyvitamin D and Pancreatic Cancer Survival.

Purpose

Although vitamin D inhibits pancreatic cancer proliferation in laboratory models, the association of plasma 25-hydroxyvitamin D [25(OH)D] with patient survival is largely unexplored.

Patients and methods

We analyzed survival among 493 patients from five prospective US cohorts ...
S-EPMC5012662 | biostudies-literature
GenomicsThe Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation
The Mediator complex functions as a control center orchestrating diverse signalings, gene activities, and biological processes. However, how Mediator subunits determine distinct cell fates remains to be fully elucidated. Here, we show that Mediator MED23 controls the cell fate preference that direct...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-40369 | biostudies-arrayexpress
UnknownAn Investigation of the Mechanical Properties of Ti Films Reinforced with Wood Composites by Growing Ti Particles on a Wood Substrate.
Table tennis racquet blades (TTRBs) are specialized wood materials known for their excellent mechanical properties. As one of the widely used physical vapor deposition technologies, magnetron sputtering has become the most effective method for preparing various thin film materials. In this study, th...
S-EPMC11902493 | biostudies-literature
UnknownTreatment of Modified Dahuang Fuzi Decoction on Cognitive Impairment Induced by Chronic Kidney Disease through Regulating AhR/NF-κB/JNK Signal Pathway.

Aim

An increasing widespread of chronic kidney disease (CKD) has been established lately around the globe. In addition to renal function loss, CKD can also cause cognitive impairment (CI). Modified Dahuang Fuzi Decoction (MDFD) is used as a traditional Chinese therapy for CKD. The effect of ...
S-EPMC9023153 | biostudies-literature
UnknownThe efficacy and safety of tivantinib in the treatment of solid tumors: a systematic review and meta-analysis.

Background

Tivantinib was designed to kill cancers by targeting the mesenchymal-epithelial transition (MET) protein. Although numerous tivantinib clinical trials are ongoing, tivantinib's efficacy and safety are still not clear. This meta-analysis was done to evaluate tivantinib's efficacy a...
S-EPMC5762579 | biostudies-literature
ProteomicsAn optimized proteomics approach reveals novel alternative proteins in mouse liver development
Alternative open reading frames (AltORFs) are unannotated sequences in genome that encode novel peptides or proteins named alternative proteins (AltProts). Although ribosome profiling and bioinformatics predict a large number of AltProts, mass spectrometry (MS) as the only direct way of identificati...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-23 | PXD033940 | Pride
Liver development. Mass spectrometry Fractionation Alternative open reading frames (altorfs) Alternative proteins (altprots) Enrichment 
UnknownAdvanced Design and Fabrication of Dual-Material Honeycombs for Improved Stiffness and Resilience.
Auxetic re-entrant honeycomb (AREH) structures, consisting of a single soft or tough material, have long faced the challenge of balancing stiffness and rebound resilience. To achieve this balance, dual-material printing technology is employed to enhance shock absorption by combining layers of soft a...
S-EPMC10673381 | biostudies-literature
UnknownAccelerated Stimulated Raman Projection Tomography by Sparse Reconstruction From Sparse-View Data.

Objective

Stimulated Raman projection tomography (SRPT), a recently developed label-free volumetric chemical imaging technology, has been reported to quantitatively reconstruct the distribution of chemicals in a three-dimensional (3D) complex system. The current image reconstruction scheme u...
S-EPMC7329365 | biostudies-literature
UnknownPOSTAR3: an updated platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins.
RNA-binding proteins (RBPs) play key roles in post-transcriptional regulation. Accurate identification of RBP binding sites in multiple cell lines and tissue types from diverse species is a fundamental endeavor towards understanding the regulatory mechanisms of RBPs under both physiological and path...
S-EPMC8728292 | biostudies-literature
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