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Transcriptomicssmall non-coding RNA sequencing of human cumulus cells from patients with or without Diminished ovarian reserve
This group consist of human embryologists from the reproductive medical center for of the 1st affiliated hospital of Anhui Medical University. Our research is specifically focused on women ovarian reserve and the relevant female infertility. By deep sequencing, the current experiment determined the ...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-MTAB-3913 | biostudies-arrayexpress
ProteomicsQuantitative proteomics analysis of Elp3 deficient bone marrow derived macrophages aggragates with or without IL-4 treatment
Alternative macrophages are critical in parasites defense, the resolution of inflammation and wound healing. RNA modifications, which are defined as post-transcriptional changes in the chemical composition of RNA molecules, are involved in the immune response.Among tRNA-modifying enzymes which targe...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-12 | PXD023588 | Pride
Aggregates Mouse bone marrow derived macrophages 
ProteomicsThe proteomic of IL-4 treated BMDMs from Wt and Elp3 KO mice
This experiement aims to know what the differences of protein translation are in the bone marrow derived macro-phages(BMDMs) from WT mice and Elp3 KO mice. We treated the BMDMs with or without IL-4 for 4 hours.
ORGANISM(S): Mus musculus (Mouse) 
2022-09-12 | PXD033962 | Pride
M2 macrophages  il-4  elp3 
ProteomicsProteomic identification of GAP-binding proteins in colorectal cancer reveals PPP1CA as a direct target of microbial GABA-mediated metabolic rewiring
This dataset corresponds to the proteomic analysis presented in Figure 6A of the manuscript “Obesity-driven microbial GABA depletion promotes metabolic rewiring and colorectal cancer progression.” We performed Drug Affinity Responsive Target Stability (DARTS) and co-immunoprecipitation proteomics us...
ORGANISM(S): Homo sapiens (Human) 
2026-06-21 | PXD069744 | Pride
Gaba  gap  ppp1ca 
ProteomicsMass spectrometry analyzed human IL-33 interaction networks under various stimulations
C-terminal HA tagged hIL-33 were ectopically expressed in HEK293T cells for 24 hours, and demonstrated with indicating stimulations (Ctrl: without stimulations, Pap: 10ug/mL papain exposure for 30min, AS: 0.5mM arsenite exposure for 1hour). Cell lysates were collected for HA-immunoprecipitation and ...
ORGANISM(S): Homo Sapiens 
PXD033460 |
TranscriptomicsMolecular signature in human cumulus cells related to embryonic developmental potential
The objective of the present study was to investigate gene expression profiles of human Cumulus cells isolated from oocytes at metaphase II stage, under controlled ovarian stimulation (COS) cycle and to evaluate the relationship of embryo quality with molecular signatures in Cumulus cells. This stu...
ORGANISM(S): Homo sapiens 
2014-04-05 | E-GEOD-54135 | biostudies-arrayexpress
TranscriptomicsMIWI and piRNA-mediated cleavage of messenger RNAs in mouse testes
The piRNA machinery is known for its role in mediating epigenetic silencing of transposons. Recent studies suggest that this function also involves piRNA-guided cleavage of transposon-derived transcripts. As many piRNAs also appear to have the capacity to target diverse mRNAs, this raises the intrig...
ORGANISM(S): Mus musculus 
2015-04-09 | E-GEOD-67683 | biostudies-arrayexpress
TranscriptomicsIL-27 Inhibits HIV-1 Infection in Human Macrophages by Down-regulating Host Factor SPTBN1 during Monocyte to Macrophage Differentiation
The susceptibility of macrophages to HIV-1 infection is modulated during monocyte differentiation. IL-27 is an anti-HIV cytokine that also modulates monocyte activation. Here, we present new evidence that IL-27 promotes monocyte differentiation into macrophages that are non-permissive for HIV-1 infe...
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-43595 | biostudies-arrayexpress
TranscriptomicsGenome-scale analysis of DNA methylation in rheumatic heart disease
The aim of the current study is to identify DNA methylation markers associated with rheumatic heart disease with secondary pulmonary arterial hypertension (RHD-PAH). Genome-wide DNA methylation study is performed among 6 RHD-PAH patients and 6 healthy controls using Illumina HumanMethylation 450K ar...
ORGANISM(S): Homo sapiens 
2016-07-06 | E-GEOD-84003 | biostudies-arrayexpress
TranscriptomicsMapping of Hepatic Expression Quantitative Trait Loci (eQTLs) in a Han Chinese Population [SNP analysis]
Elucidating the genetic basis underlying the variation in hepatic gene expression is of importance to understand disease etiology and drug metabolism variances. To date, no genome-wide eQTL analysis has been conducted in the Han Chinese, the largest ethnic group in the world. We performed a genome-w...
ORGANISM(S): Homo sapiens 
2015-01-02 | E-GEOD-53790 | biostudies-arrayexpress
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