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ProteomicsEnsemble and iterative engineering for maximal bioconversion to the blue pigment, Indigoidine from non-canonical sustainable carbon sources.
While many heterologous molecules can be produced at trace concentrations via microbial bioconversion processes, maximizing their titers, rates, and yields from lignin-derived carbon streams remains challenging. Strong growth coupling can not only increase titers and yields but also shift the produc...
ORGANISM(S): Pseudomonas putida KT2440 
2024-02-29 | PXD040697 | Pride
Emergent cell phenotypes Lignin Growth coupling Recombineering Proteomics analysis Ale Bioproduction Heterologous pathway Crispr Indigoidine Genome scale metabolic models Strain engineering 
UnknownProduction of tetra-methylpyrazine using engineered Corynebacterium glutamicum.
Not available
S-EPMC6926172 | biostudies-literature
UnknownSpacer-type tibial osteotomy versus open wedge high tibial osteotomy and unicompartmental knee arthroplasty for Kellgren-Lawrence grade 3-4 medial unicompartmental knee osteoarthritis in patients younger than 65 years.
Not available
S-EPMC11771026 | biostudies-literature
TranscriptomicsTranscription profiling of chicken develomental time series of the retinal pigment epithelia
Purpose: The morphology of the RPE shows minimal change as the neural retina and choriocapillaris differentiate. Nonetheless, initial studies of barrier-related proteins suggest extensive remodeling of the RPE in response to this changing environment. A genomic approach was used to investigate the e...
ORGANISM(S): Gallus gallus 
2008-11-08 | E-GEOD-7176 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of differentiating human erythroblasts
Human erythroblasts purified from cord blood were cultured in vitro and FACS-sorted into five highly purified populations representing distinct differentiation stages:  proerythroblasts, early basophilic erythroblasts, late basophilic erythroblasts, polychromatophilic erythroblasts, and orthochromat...
ORGANISM(S): Homo sapiens 
2013-12-25 | E-GEOD-53635 | biostudies-arrayexpress
ProteomicsMulti-layered metabolic remodeling of Pseudomonas putida for efficient conversion of lignocellulosic sugars to a precursor of advanced aviation fuel
Isoprenyl acetate, a volatile ester derived from isoprenol, is a key biosynthetic intermediate for a candidate for next-generation aviation fuel, 1,4-dimethylcyclooctane. Here, we engineered Pseudomonas putida KT2440 for the production of isoprenyl acetate from mixed sugar substrates. We first gener...
ORGANISM(S): Pseudomonas putida KT2440 
2026-03-23 | PXD067010 | Pride
Esterase knockout Isoprenol Advanced aviation fuel Catabolite repression Isoprenyl acetate Lignocellulosic feedstocks T-brsc 
ProteomicsProduction of isoprenol using the IPP-bypass pathway in Rhodosporidium toruloides
There is increasing demand for domestically generated-bioderived aviation fuels to strengthen the national energy supply while also reducing carbon emissions. Developing these supply chains provides an opportunity to explore novel aviation fuel components, such as 1,4-dimethylcyclooctane (DMCO). In ...
ORGANISM(S): Rhodotorula toruloides 
2026-04-09 | PXD064428 | Pride
Isoprenol  rhodosporidium toruloides  ipp-bypass pathway  phosphatase  advanced biofuel  sustainable aviation fuel jbei 
ProteomicsAdaptive evolution of Methylotuvimicrobium alcaliphilum to grow in the presence of rhamnolipids improves fatty acid and rhamnolipid production from CH4
Rhamnolipids (RL) are well-studied biosurfactants naturally produced by pathogenic strains of P. aeruginosa. Current methods to produce RLs in native and heterologous hosts have focused on carbohydrates as production substrate; however CH4 provides an intriguing alternative as a substrate for RL pro...
ORGANISM(S): Methylomicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z) 
2022-09-19 | PXD029605 | Pride
Methylotuvimicrobium alcaliphilum Adaptive laboratory evolution Rhamnolipids Ch4 
ProteomicsAdaptive lab evolution and omics characterization enable tolerance engineering of Pseudomonas putida KT2440 to produce the jet-fuel precursor isoprenol
Pseudomonas putida KT2440 (KT2440) has been established as an industrially relevant chassis for the production of the jetfuel precursor isoprenol. However, this strain assimilated isoprenol as sole carbon source and also showed impaired growth at isoprenol concentrations > 2 g/L which is a significa...
ORGANISM(S): Pseudomonas putida KT2440 
2025-05-28 | PXD054609 | Pride
Pseudomonas putida Sustainable aviation fuel Isoprenol Adaptive laboratory evolution Tolerance engineering 
UnknownDatabase of ab initio L-edge X-ray absorption near edge structure.
Not available
S-EPMC8196187 | biostudies-literature
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