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MetabolomicsAirway Dysbiosis Accelerates Lung Function Decline in Chronic Obstructive Pulmonary Disease (Human UPLC-MS/MS assays)

Progressive decline in lung function is a hallmark of chronic obstructive pulmonary disease (COPD). Although airway dysbiosis occurs in COPD, whether it contributes to disease progression remains unknown. Here, through a longitudinal analysis on 181 COPD individuals from two large cohorts involvi...

2023-06-12 | MTBLS5423 | MetaboLights
MetabolomicsAirway Dysbiosis Accelerates Lung Function Decline in Chronic Obstructive Pulmonary Disease (Murine UPLC-MS/MS assays)

Progressive lung function decline is a hallmark of chronic obstructive pulmonary disease (COPD). Airway dysbiosis occurs in COPD, but whether it contributes to disease progression remains unknown. Here we showed, through a longitudinal analysis on two cohorts involving four UK centers, that basel...

2023-06-12 | MTBLS6894 | MetaboLights
UnknownIdentification of a New Function of Cardiovascular Disease Drug 3-Morpholinosydnonimine Hydrochloride as an Amyloid-β Aggregation Inhibitor.
Not available
S-EPMC6044715 | biostudies-literature
ProteomicsLC-MS characterization of anti-PD-L1 and CXCR4 bispecific nanobodies
Antibodies and derivative drugs targeting immune checkpoints have been approved for the treatment of several malignancies, but there are fewer responses in patients with pancreatic cancer. Here, we designed a nanobody molecule with bi-targeting on PD-L1 and CXCR4, as both targets are overexpressed i...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037102 | Pride
Nanobody Lc-ms Bispecific Protein Complete mw 
MetabolomicsThe gut microbiota contributes to changes in the host immune response induced by Trichinella spiralis
The gut microbiota plays an important role in parasite-host interactions and the induction of immune defense responses. Trichinella spiralis is an important zoonotic parasite that can directly or indirectly interact with the host in the gut. Changes in the gut microbiota following infection with T. ...
2023-08-07 | MTBLS7603 | MetaboLights
ProteomicsProteomic profiling reveals the impact of surface functionalization on the protein corona formed on superparamagnetic iron oxide nanoparticles
The protein corona formed on the surface of nanomaterials is critical to understanding their biological behavior, as it is regulated by both the physicochemical properties of the nanomaterials and the physiological environment. The interplay between material synthesis characteristics, protein corona...
ORGANISM(S): Homo Sapiens 
2024-10-14 | PXD056769 |
ProteomicsThe protective effect of Liquiritin in hypoxia/reoxygenation-induced disruption on blood brain barrier
Stroke is the second leading cause of death in human life health, but current treatment strategies are limited to thrombolytic therapy, and because of the tight time window, many contraindications, and only a very small number of people can benefit from it, new therapeutic strategies are needed to s...
ORGANISM(S): Homo Sapiens 
2021-04-25 | PXD025605 |
ProteomicsIntegrative Comparative Proteomics Identifies Core Differentially Expressed Proteins and Pathways for Drought Tolerance by Exploiting Contrasting Rice Varieties
More tightly coordinated response was revealed at the protein level in the tolerant varieties by proteomic analysis. Carbohydrate metabolism, redox homeostasis and protein transport were found activated in the tolerant varieties in functional enrichment analysis; while photosynthesis was suppressed....
ORGANISM(S): Oryza Sativa 
2026-01-11 | PXD072923 |
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