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TranscriptomicsLarge-scale identification and comparative analysis of miRNA expression profile in the respiratory tree of the sea cucumber Apostichopus japonicus during aestivation (part 1)
The sea cucumber Apostichopus japonicus withstands high water temperatures in the summer by suppressing metabolic rate and entering a state of aestivation. We hypothesized that changes in the expression of miRNAs could provide important post-transcriptional regulation of gene expression during hypom...
ORGANISM(S): Apostichopus japonicus 
2014-10-01 | E-GEOD-52224 | biostudies-arrayexpress
TranscriptomicsHigh-throughput sequencing reveals differential expression of miRNAs in intestine from sea cucumber during aestivation [microarray]
The regulatory role of miRNA in gene expression is an emerging hot new topic in the control of hypometabolism. Sea cucumber aestivation is a complicated physiological process that includes obvious hypometabolism as evidenced by a decrease in the rates of oxygen consumption and ammonia nitrogen excre...
ORGANISM(S): Apostichopus japonicus 
2014-06-06 | E-GEOD-48868 | biostudies-arrayexpress
TranscriptomicsTranscriptome conservation of the D. discoideum and D. purpureum developmental programs revealed through RNA-sequencing
Cross species comparison of genomes and transcriptomes is a powerful tool for understanding underlying biological processes, accurate functional classification of genes, and discovery of novel elements. The shift to next-generation sequencing platforms has tremendously accelerated the analysis of ge...
ORGANISM(S): Dictyostelium purpureum 
2010-03-12 | E-GEOD-17637 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiles of brain glioma stem cells and normal neural stem cells
A human cDNA microarray comprising 29,187 human genome probes was used to evaluate the transcriptional changes between brian glioma stem cells (GSC) and normal neural stem cells(NSC). There were 6 samples that were analyzed, 3 samples were from glioma stem cells and the other 3 samples form normal n...
ORGANISM(S): Homo sapiens 
2014-07-30 | E-GEOD-41031 | biostudies-arrayexpress
TranscriptomicsArgonaute2 mediates compensatory expansion of the pancreatic M-CM-^_-cell
Pancreatic M-CM-^_-cells adapt to compensate for the increased metabolic demand during insulin resistance. While the microRNA pathway has an essential role in the expansion of M-CM-^_-cell mass, the extent of its contribution is unclear. Here we show that miR-184 is silenced in the pancreatic islets...
ORGANISM(S): Mus musculus 
2014-02-06 | E-GEOD-46623 | biostudies-arrayexpress
TranscriptomicsBrain glioma stem cells and normal neural stem cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-07-30 | E-GEOD-41033 | biostudies-arrayexpress
TranscriptomicsMyeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-M-NM-:B gene network
Chromosome 5q deletions (del(5q)) are common in high-risk (HR) Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML); however, the gene regulatory networks that sustain these aggressive diseases are unknown. Reduced miR-146a expression in del(5q) HR-MDS/AML and miR-146a-/- hematopoietic st...
ORGANISM(S): Homo sapiens 
2014-08-23 | E-GEOD-60649 | biostudies-arrayexpress
TranscriptomicsThe prognostic and predictive value of a six-microRNA-based classifier in stage II colon cancer
microRNA profiling of colon tumor tissues vs adjacent normal tissues 40 paired tumor and adjacent normal tissues of stage M-bM-^EM-! colon caner
ORGANISM(S): Homo sapiens 
2013-11-29 | E-GEOD-49246 | biostudies-arrayexpress
TranscriptomicsBacterial discrimination by Dictyostelid amoebae reveals the complexity of ancient interspecies interactions
Transcriptional profiling of D. discoideum revealed sets of genes whose expression is enriched in amoebae interacting with different species of bacteria, including sets that appear specific to amoebae interacting with Gram(+), or with Gram(-) bacteria. In a genetic screen utilizing the growth of mut...
ORGANISM(S): Dictyostelium discoideum 
2013-05-20 | E-GEOD-46386 | biostudies-arrayexpress
TranscriptomicsDifferential microRNA Expression during Muscle Regeneration
MicroRNAs (miRNAs) are important in the regulation of many biological processes including muscle development. However, little is known regarding miRNA regulation of muscle regeneration. In mature murine tibialis anterior muscle following injury, 298 miRNAs were significantly changed during the time ...
ORGANISM(S): Mus musculus 
2012-04-24 | E-GEOD-37479 | biostudies-arrayexpress
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