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ProteomicsProteomic analysis for Cisplatin -induced mice spermatogenesis defects
Cisplatin is a crucial chemotherapeutic agent for treating various cancers, but excessive use can cause irreversible damage to the reproductive system. However, the protein expression profile of cisplatin-induced testicular injury remains poorly understood. In this study, we observed that cisplatin ...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-03 | PXD061652 | Pride
Human，spermatogenesis Spermatogenic injury Cisplatin 
MetabolomicsMetabolomic and Transcriptomic Profiling of Two Closely Related Species within the Genus Oldenlandia

The genus Oldenlandia encompasses numerous medicinal plants with significant pharmacological potential, yet their tissue-specific metabolic pathways and transcriptional profiles remain understudied. This study combined transcriptomic and metabolomic analyses to compare the differences in five ti...

2026-01-16 | MTBLS13314 | MetaboLights
TranscriptomicsDirect reprogramming of human fibroblasts to functional hepatocyte-like cells
Plasticity of differentiated cells has been proved by nuclear transfer, induced pluripotent cells and transdifferentiation. Here we show that by transduction of 3 factors (FOXA3, HNF1A and HNF4A), human fetal fibroblasts can be converted to hepatocyte-like cells (hiHep cells), expressing hepatic mar...
ORGANISM(S): Homo sapiens 
2014-03-06 | E-GEOD-42643 | biostudies-arrayexpress
ProteomicsPhosphoproteome and proteome of mouse hepatocyte maturation and human hepatic reprogramming
To identify central protein kinases that potentially promote the maturation, we chemically induced liver progenitor cells (CLiPs) from mouse hepatocytes using a previously established protocol, and profiled the phosphoproteome and proteome of freshly isolated primary mouse hepatocytes (MHs) and ALBU...
ORGANISM(S): Homo Sapiens Mus Musculus 
2022-08-05 | PXD035829 |
GenomicMIDCIRS Reveals Antibody Diversification in Young Children with Malaria

This study describes a novel Immune Repertoire Sequencing technique, termed Molecular Identifier Clustering-based Immune Repertoire Sequencing (MIDCIRS), to reduce sequencing error while maintaining extremely high coverage and applies this technique to investigate the differential immune response...

phs001209 | dbGaP
ProteomicsMS analysis of endogenously precipitated DDX20 protein complexes (immunoprecipitation (IP)–MS)
Protein lysates were derived from HEK293T cells and spermatogonial stem cells，and interacting proteins were “pulled-down” for analysis by gel electrophoresis and identification by mass spectrometry. An equal amount of non-specific IgG from rabbit serum (Thermos Fisher Scientific) was used as a negat...
ORGANISM(S): Homo Sapiens Mus Musculus 
PXD038171 |
ProteomicsProteomic analysis of the effects of DDX20 deletion in spermatogonia
To investigate the role of DDX20 in spermatogenesis, we generated Ddx20 flox/flox Ddx4-Cre mice to make a germ cell-specific Ddx20 knockout, and isolated spermatogonia from four-day-old mouse testes by THY1 magnetic beads. We then performed proteomic analysis using protein lysates obtained from THY1...
ORGANISM(S): Mus Musculus 
PXD038170 |
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