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MetabolomicsIntegrated multi-omics analysis and experimental verification reveal the involvement of the PI3K/Akt signaling pathway in myometrial fibrosis of adenomyosis.

This analysis established comprehensive metabolomic profiles of adenomyosis patients and revealed widespread alterations in the metabolome within normal and fibrotic myometrium. Integrated analysis shown significant associations between metabolomic data and fibrosis . This study is the first to d...

2025-05-12 | MTBLS11965 | MetaboLights
ProteomicsComparative proteomics of defense response to AAL toxin
A comparative proteomics analysis on AAL toxin treated jai1 mutant and its wild type revealed that JA pathway promoted AAL toxin induced PCD by regulating the relevant PCD components and/or through other hormone pathways in a SlCOI1 dependent manner.Additional contact:
ORGANISM(S): Solanum lycopersicum 
2016-06-27 | PXD002864 | Pride
Solanum lycopersicum  aal toxin  programmed cell death 
ProteomicsProteomic Analysis Reveal Myometrial Fibrosis of Adenomyosis(Human,adenomyosis,tissue,LC-MSMS)
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was utilized to analyze adenomyotic and normal myometrial tissues from ten AM patients who underwent hysterectomy with myometrial fibrosis confirmed by Masson staining. This analysis established comprehensive proteomic profiles of adenomyosi...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058989 | Pride
Human Adenomyosis Tissue Lc-msms 
ProteomicsThe involvement of autophagy in mesaconitine-induced neurotoxicity in HT22 cells revealed through integrated transcriptomic, proteomic, and m6A epitranscriptomic profiling
In order to investigate the effects of mesaconitine treatment on protein expression, we carried out quantitative proteomic analysis to elucidate comprehensive protein changes in HT22 cells with or without mesaconitine treatment.
ORGANISM(S): Mus Musculus 
2024-05-03 | PXD052001 |
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