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Genomicsena-DATASET-BGI-26-11-2015-07:58:13:440-13 - samples
Esophageal cancer is one of the most aggressive cancers and the sixth leading cause of cancer death worldwide1. Approximately 70% of the global esophageal cancers occur in China and over 90% histopathological forms of this disease are esophageal squamous cell carcinoma (ESCC)2-3. Currently, there ar...
EGAD00001001691 | EGA
GenomicsWhole-genome sequencing in 14 cases and whole-exome sequencing in 90 cases of Chinese ESCC
Esophageal cancer is one of the most aggressive cancers and the sixth leading cause of cancer death worldwide1. Approximately 70% of the global esophageal cancers occur in China and over 90% histopathological forms of this disease are esophageal squamous cell carcinoma (ESCC)2-3. Currently, there ar...
EGAS00001001487 | EGA
ProteomicsSrc heterodimerically activates Lyn or Fyn to serve as targets for esophageal squamous cell carcinoma (ESCC) diagnosis and treatment
we combined phosphoproteomics and several cellular and molecular biologic strategies to identify that Src specifically interacted with the members of Src-family kinases (SFKs), such as Fyn or Lyn to form heterodimers, and subsequently phosphorylate the tyrosine sites in SH2 and kinase domains, which...
ORGANISM(S): Homo Sapiens 
2022-03-15 | PXD032306 |
ProteomicsQuantitative Proteome of Infant Stenotic Ureters Reveals Extracellular Matrix Organization and Oxidative Stress Dysregulation Underlying Ureteropelvic Junction Obstruction
Ureteropelvic junction obstruction (UPJO) is the most frequent cause of congenital hydronephrosis in child. To better investigate the molecular mechanisms of this pathological process, we performed data independent acquisition-based proteomics to compare the stenotic ureter proteome of UPJO in infan...
ORGANISM(S): Homo Sapiens 
2020-08-17 | PXD020116 |
ProteomicsHuman colon cancer HCT116 cell LC/MSMS
Mitosis deregulation is a key event during carcinogenesis. Alternative splicing spectrum alteration plays a critical role during mitosis shift. However, the molecules responsible for dysregulated alternative splicing driving carcinogenetic mitosis remain poorly defined. Here, we demonstrate that can...
ORGANISM(S): Homo Sapiens 
2020-03-30 | PXD018242 |
ProteomicsPSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation
MDA-MB-231 cells with expression of Flag-GPX4 were treated with IFNg. An immunoprecipitation assay was performed, and immunoprecipitates were subjected to masspec analysis.
ORGANISM(S): Homo Sapiens 
2025-03-01 | PXD061373 |
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