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MetabolomicsSensing Ceramides by CYSLTR2 and P2RY6 to Aggravate Atherosclerosis

Recent evidence shows elevated circulating long-chain ceramide levels predicts atherosclerotic cardiovascular disease (ASCVD) independently of cholesterol. Although targeting ceramides signaling may provide therapeutic benefits beyond the treatment of hypercholesterolemia, the underlying mechanis...

2025-04-15 | MTBLS11925 | MetaboLights
MetabolomicsCD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12<sup>+</sup> microglia transformation.
CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
2025-08-04 | MTBLS11084 | MetaboLights
UnknownLoss of Y chromosome and its implications in male amyotrophic lateral sclerosis: insights from the UK Biobank.
Not available
S-EPMC12836765 | biostudies-literature
TranscriptomicsDegradome sequencing reveals endogenous small RNA targets in rice (Oryza sativa L. ssp. indica)
MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) regulate gene expression in eukaryotes. Plant miRNAs modulate their targets mainly via messenger RNA (mRNA) cleavage. Small RNA targets have been extensively investigated in Arabidopsis using computational prediction, experimental validation, an...
ORGANISM(S): Oryza sativa Indica Group 
2010-01-01 | E-GEOD-19050 | biostudies-arrayexpress
UnknownA global analysis of Y-chromosomal haplotype diversity for 23 STR loci.
Not available
S-EPMC4127773 | biostudies-literature
TranscriptomicsRNA-seq from control and macroH2A1-depleted IMR90 primary human lung fibroblasts
The histone variant macroH2A1 and the poly(ADP-ribose) polymerase PARP-1 both regulate gene transcription by modulating chromatin structure and function. Of the two macroH2A1 splice variants, macroH2A1.1 and macroH2A1.2, the former is often suppressed in cancer and has the unique ability to interact...
ORGANISM(S): Homo sapiens 
2014-09-15 | E-GEOD-54846 | biostudies-arrayexpress
UnknownVarious Profiles of tet Genes Addition to tet(X) in Riemerella anatipestifer Isolates From Ducks in China.
Not available
S-EPMC5880999 | biostudies-literature
UnknownType B Chloramphenicol Acetyltransferases Are Responsible for Chloramphenicol Resistance in Riemerella anatipestifer, China.
Not available
S-EPMC5331189 | biostudies-literature
UnknownEfficient synthesis of primary and secondary amides via reacting esters with alkali metal amidoboranes.
Not available
S-EPMC8514480 | biostudies-literature
UnknownHippocampal PACAP signaling activation triggers a rapid antidepressant response.
Not available
S-EPMC11265467 | biostudies-literature
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