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ProteomicsIdentification of potential substrates of TRABID in HeLa cells using SILAC
Immune checkpoint blockades (ICBs) have been approved for treating multiple cancer types, but the response rate is limited for many solid tumors. Much efforts have been devoted to understand the mechanisms governing ICB therapy efficacy and the abundance of tumor-infiltrating lymphocytes is among th...
ORGANISM(S): Homo sapiens (Human) 
2023-05-11 | PXD035002 | Pride
Trabid 
ProteomicsLong noncoding RNA BCRP3 stimulates VPS34 and autophagy activities to promote protein homeostasis and cell survival
Background: Autophagy plays important roles in cell homeostasis and protein quality control. Long non-coding RNAs (lncRNAs) have been revealed as an emerging class of autophagy regulators, but the majority of them function in regulating the expression of autophagy-related genes. LncRNAs that directl...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030756 | Pride
Autophagy Vps34 complex Protein quality control Tgf- signaling Lncrna Cell death. 
Proteomicsusp11 overexpression in neuron derived from mESCs for proteome and ubiquitylome analyses
Using unbiased mass spectrometry-based screen to identify differences in ubiquitinated proteins in the overexpression of Usp11. To focus on potential substrates relevant for Usp11’s role in neurogenesis, we performed experiments with mouse embryonic stem (ES) cells, in which NPC and neurons are deri...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-29 | PXD021189 | Pride
Mescs Ubiquitylome analyses Usp11 
ProteomicsWDR4 conditional knockout in mouse cerebellar granule progenitors for proteome analysis
To uncover candidates which are WDR4 downstream effectors regulating cerebellar granule neuron proliferation phenotype, we utilized quantitative proteomics analysis (TMT labeling) with granule neuron progenitors from P7 wdr4 conditional knockout (using Atoh1-Cre) and control cerebella.
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD022319 | Pride
Granule progenitors Mouse Tmt Wdr4 Cerebellum 
ProteomicsPTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target
Aberrant overexpression or activation of EGFR drives the development of non-small cell lung cancer (NSCLC) and acquired resistance to EGFR tyrosine kinase inhibitors (TKIs) by secondary EGFR mutations or c-MET amplification/activation remains as a major hurdle for NSCLC treatment. We previously iden...
ORGANISM(S): Homo sapiens (Human) 
2023-10-09 | PXD025361 | Pride
Human Lung 
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