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TranscriptomicsHuman breast cancer cells: control vs treated with breast cancer patients' sera
To investigate the significant differently expressed genes upon the stimulation of breast cancer patients' sera. Cells were untreated or treated with 10% breast cancer patients' sera for 24h followed by isolation of total RNA using TRIZOL. Gene-expression profiling was performed on the CapitalBio 35...
ORGANISM(S): Homo sapiens 
2012-08-14 | E-GEOD-40108 | biostudies-arrayexpress
ProteomicsFOXA1 O-GlcNAcylation-mediated transcriptional switch governs metastasis capacity in breast cancer
The forkhead protein FOXA1 has been found to play a critical role in orchestrating hormonal-signaling network and to function as a pioneer factor to regulate breast-specific gene expression,However, whether interplay between O-GlcNAcylation and FOXA1 affects the genome-wide transcriptional activity ...
ORGANISM(S): Homo Sapiens 
2022-12-21 | PXD039019 |
ProteomicsChromatin-associated OGT promotes hepatocellular carcinoma malignancy via activating ZNF263
OGT, the only facilitator which attaches the monosaccharide to many oncogenic factors or tumor suppressors, has been suggested to play an influential role in tumorigenesis and metastasis of HCC. OGT interactome analyses indicates that disordered OGT may serve as a hub protein to activate the buildin...
ORGANISM(S): Homo Sapiens 
2023-01-12 | PXD039365 |
ProteomicsO-GlcNAcylation elevates topoisomerase IIα catalytic activity: a role in the chemotherapy resistance of breast cancer
DNA topoisomerase IIα (TOP2A) plays a vital role in replication and cell division by catalytically altering DNA topology. It is a prominent target for anticancer drugs. However, it is currently unknown whether TOP2A is O-GlcNAc-modified, and the mechanism by which interplay between TOP2A and O-GlcNA...
ORGANISM(S): Homo Sapiens 
2023-03-31 | PXD041284 |
ProteomicsProteomic profiling of the global protein changes of Neuro-2a cells treated with dFUS-E9C or control
We conducted unbiased mass spectrometric experiments to evaluate the specificity of dFUS-E9C. In these studies, Neuro-2a cells were treated with dFUS-E9C. The result revealed the detection of more than 5000 proteins, among which there was a notable degradation of FUS, confirming the targeted action ...
ORGANISM(S): Mus Musculus 
2025-04-04 | PXD062671 |
ProteomicsProteomic profiling of the global protein changes of Neuro-2a cells treated with siFUS or control
We conducted unbiased mass spectrometric experiments to evaluate the specificity of siFUS. In these studies, Neuro-2a cells were treated with siFUS. The result revealed the detection of more than 5000 proteins, among which there was a notable degradation of FUS, confirming the targeted action of siF...
ORGANISM(S): Mus Musculus 
2025-04-07 | PXD062670 |
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