Chen Tian-Wei TW

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PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1

Our study have shown that PPDPF promoted NF-κB activation through TRIM21-mediated K63-linked ubiquitination of RIPK1 in hepatocytes. Upon TNF-α stimulation, PPDPF enhances TRIM21/RIPK1 interaction and increases TRIM21-mediated K63-linked ubiquitination of RIPK1, which promotes NF-κB activation.To ma...

ORGANISM(S): Homo Sapiens

2023-02-21 | PXD040301 |

Genetics and Environment Distinctively Shape the Human Immune Cell Epigenome.

The epigenomic landscape of human immune cells is dynamically shaped by both genetic factors and environmental exposures. However, the relative contributions of these elements are still not fully understood. In this study, we employed single-nucleus methylation sequencing and ATAC-seq to systematica...

S-EPMC10327221 | biostudies-literature

The sequence and de novo assembly of the giant panda genome.

Using next-generation sequencing technology alone, we have successfully generated and assembled a draft sequence of the giant panda genome. The assembled contigs (2.25 gigabases (Gb)) cover approximately 94% of the whole genome, and the remaining gaps (0.05 Gb) seem to contain carnivore-specific rep...

S-EPMC3951497 | biostudies-literature

Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study.

Background

Rates of acute intracerebral hemorrhage (ICH) increase in winter months but the magnitude of risk is unknown. We aimed to quantify the association of ambient temperature with the risk of ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2) ...

S-EPMC4747478 | biostudies-literature

Optimal achieved blood pressure in acute intracerebral hemorrhage: INTERACT2.

Objectives

To investigate the effects of intensive blood pressure (BP) lowering according to baseline BP levels and optimal achieved BP levels in patients with acute intracerebral hemorrhage (ICH).

Methods

INTERACT2 was an open, blinded endpoint, randomized controlled trial in 2,839 p...

S-EPMC4336065 | biostudies-literature

Intracerebral hemorrhage location and outcome among INTERACT2 participants.

Objective

To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2).