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TranscriptomicsEnhanced Pathogenicity of Th17 cells Generated in the Absence of Transforming Growth Factor-β Signaling
CD4+ T cells that selectively produce interleukin (IL)-17, are critical for host defense and autoimmunity1-4. Crucial for T helper17 (Th17) cells in vivo5,6, IL-23 has been thought to be incapable of driving initial differentiation. Rather, IL-6 and transforming growth factor (TGF)-β1 have been argu...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-23505 | biostudies-arrayexpress
UnknownRETRACTED: circTulp4 functions in Alzheimer’s disease pathogenesis by regulating its parental gene, Tulp4
Not available
S-EPMC8178447 | biostudies-literature
MetabolomicsTGF-β uncouples glycolysis and inflammation in macrophages and controls the survival during sepsis

The mechanisms by which macrophage metabolism is regulated and the effects of metabolism on diseases remain largely unknown. We show here that TGF-β regulates the glycolysis of macrophages independently of inflammatory cytokine production, and thus affects the survival in experimental sepsis. Spe...

2023-02-17 | MTBLS6886 | MetaboLights
ProteomicsMulti-organ Proteomic and Phosphoproteomic Profiles of Mpox Virus Infection in SIVmac239-infected Rhesus Macaques
Macaque study was conducted in an ABSL-3 facility, adhering to protocols approved by the Institutional Animal Care and Use Committee (IACUC) under the guidelines of the Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (Approval Number XJ23004). All animals were single-hous...
ORGANISM(S): Macaca Mulatta 
PXD056753 |
ProteomicsCharacterization of kidney-specific and site-specific N-glycosylation signatures of isolated uromodulin from human urine
Uromodulin (Umod, Tamm–Horsfall protein), as the most abundant urinary N-glycoprotein exclusively produced by the kidney, can form filaments to antagonize the adhesion of uropathogens. However, the kidney-specific and site-specific N-glycosylation signatures of this glycoprotein remain poorly unders...
ORGANISM(S): Homo Sapiens 
PXD041640 |
ProteomicsHRD1-ERAD controls production of the hepatokine FGF21 through CREBH polyubiquitination
As a ubiquitin ligase, HRD1 may regulate FGF21 expression through targeting protein degradation. We then aimed to identify proteins whose expressions are altered at post-transcriptional levels in HRD1 LKO mouse liver
ORGANISM(S): Mus Musculus 
2021-12-14 | PXD030410 |
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