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UnknownRelationships between cell cycle pathway gene polymorphisms and risk of hepatocellular carcinoma.

Aim

To investigate the associiations between the polymorphisms of cell cycle pathway genes and the risk of hepatocellular carcinoma (HCC).

Methods

We enrolled 1127 cases newly diagnosed with HCC from the Tumor Hospital of Guangxi Medical University and 1200 non-tumor patients from the...
S-EPMC4917616 | biostudies-literature
ProteomicsMice Hippocampus neuron HT22 LC-MS
Ketone 3-hydroxybutyrate (3OHB) has been proved to be a neuroprotective endogenous molecule in multiple neurodegenerative diseases, but the detailed mechanisms of action has not been fully uncovered. Here, we employed a quantitative proteomics approach to assess the global protein expression pattern...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD008053 | Pride
Neuron Central nervous system Proteomics Bivalent chromatin Histone lysine hydroxybutyrylation Ht22 Beta-hydroxybutyrate Mice Transcriptomics 
TranscriptomicsGenome-wide expression analysis in Down syndrome: dynamic variation and insight into immunodeficiency
Down syndrome (DS) is caused by triplication of Human chromosome 21 (Hsa21) and associated with an array of deleterious phenotypes, including mental retardation, heart defects and immunodeficiency. Spatio-temporal patterns of genome-wide expression are critical to the understanding of DS. We used a ...
ORGANISM(S): Homo sapiens 
2012-02-10 | E-GEOD-35665 | biostudies-arrayexpress
GenomicsGenome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cel...

phs000361.v1.p1 | EGA
Proteomicsthe MS data involved in the article "Nuclear ACAT1 orchestrates natural killer cell-dependent antitumor immunity in colorectal cancer"
In this study we aim to explore the metabolic enzyme that affects NK cell function in colorectal cancer, and mainly focus on the mechanism how nuclear ACAT1（Mitochondrial acetyl-CoA acetyltransferase）promotes NK cell infiltration and activation
ORGANISM(S): Homo Sapiens 
2025-03-18 | PXD061959 |
UnknownToripalimab Combination Therapy Without Concurrent Cisplatin for Nasopharyngeal Carcinoma: The DIAMOND Randomized Clinical Trial.

Importance

With the programmed cell death protein 1 (PD-1) blockade toripalimab, omitting highly toxic concurrent cisplatin may be feasible for nasopharyngeal carcinoma (NPC) without compromising survival.

Objective

To evaluate the efficacy and safety of toripalimab incorporated into ...
S-EPMC12371549 | biostudies-literature
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