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ProteomicsLysine-targeting, covalent inhibitors of bromodomain BD1 of BET proteins in live cells and animals
We report herein a set of activity-based probes (ABPs; P3-P7) based on various lysine-reactive covalent warheads capable of global profiling of ligandable lysine within BRDs in live cells and animals. Chemoproteomic experiments with P7 by utilizing 2-ethynylbenzaldehyde (EBA) identified 18 endogenou...
ORGANISM(S): Homo Sapiens Mus Musculus 
2025-04-10 | PXD058513 |
MetabolomicsGNPS - Proteomic and Metabolomic Characterization of COVID-19 Patient Sera MRMHR
Targeted mass spectrometric assays for the 22 proteins in a second test cohort containing 19 COVID-19 patients
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-05-30 | MSV000085515 | GNPS
MetabolomicsGNPS - Proteomic and Metabolomic Characterization of COVID-19 Patient Sera
Early detection and effective treatment of severe COVID-19 patients remain major challenges. Here, we performed proteomic and metabolomic profiling of sera from 46 COVID-19 and 53 control individuals. We then trained a machine learning model using proteomic and metabolomic measurements from a traini...
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 (ncbitaxon:2697049) Homo Sapiens (ncbitaxon:9606) 
2020-05-29 | MSV000085507 | GNPS
ProteomicsPlasma proteomics analysis of inherited thrombocytopenia 2 patients
Inherited thrombocytopenia 2 (THC2) is difficult to diagnose due to the lack of specific clinical characteristics and diagnostic methods. To identify potential plasma protein biomarkers for THC2, we collected the plasma samples from THC2 patients, and analyzed the protein profiles using the liquid c...
ORGANISM(S): Homo Sapiens 
2021-03-22 | PXD024895 |
ProteomicsProteomic and Metabolomic Characterization of COVID-19 Patient Sera MRMHR
Targeted mass spectrometric assays for the 22 proteins in a second test cohort containing 19 COVID-19 patients
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-05-30 | MSV000085515 | MassIVE
ProteomicsProteomic and Metabolomic Characterization of COVID-19 Patient Sera
Early detection and effective treatment of severe COVID-19 patients remain major challenges. Here, we performed proteomic and metabolomic profiling of sera from 46 COVID-19 and 53 control individuals. We then trained a machine learning model using proteomic and metabolomic measurements from a traini...
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 (ncbitaxon:2697049) Homo Sapiens (ncbitaxon:9606) 
2020-05-29 | MSV000085507 | MassIVE
ProteomicsSpatiotemporal and global profiling of DNA-protein interactions enables discovery of low-affinity transcription factors
Precise dissection of DNA-protein interactions is essential for elucidating recognition basis, dynamics, and gene regulation mechanism. However, global profiling of weak and dynamic DNA-protein interactions remains a long-standing challenge. Here, we establish light-induced lysine (K) enabled crossl...
ORGANISM(S): Homo Sapiens 
2023-01-03 | PXD039229 |
ProteomicsExplore the proteomics characteristics of urine and serum from COVID-19 patients
we obtained the proteome profiling of serum and urine specimen collected from 50 COVID-19 patients and 40 healthy subjects. We then used TMT-labeled proteomics and quantified 1,494 and 3,854 proteins in serum and urine, respectively. We then explored the pathogenic characteristics in body fluids aft...
ORGANISM(S): Homo Sapiens 
2021-12-30 | PXD030662 |
Proteomics[HPP-2.0] Proteomic and Metabolomic Characterization of COVID-19 Patient Sera
Early detection and effective treatment of severe COVID-19 patients remain major challenges. Here, we performed proteomic and metabolomic profiling of sera from 46 COVID-19 and 53 control individuals. We then trained a machine learning model using proteomic and metabolomic measurements from a traini...
ORGANISM(S): Homo Sapiens 
2020-05-15 | PXD019221 |
Proteomics[HPP-2.0] Proteomic and Metabolomic Characterization of COVID-19 Patient Sera MRMHR
Targeted mass spectrometric assays for the 22 proteins in a second test cohort containing 19 COVID-19 patients
ORGANISM(S): Homo Sapiens 
2020-05-16 | PXD019232 |
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