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ProteomicsAmyotrophic Lateral Sclerosis-Associated Mutants of SOD1 Perturb mRNA Splicing through Aberrant Interactions with SRSF2
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that impacts neurons in the brain and spinal cord. Although a substantial number of studies have been conducted, much remains to be learned about the cellular mechanisms underlying ALS. In this study, we employed an engineered ascor...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD050785 | Pride
Sod1 Als Affinity pulldown Lc-msms 
UnknownNovel trigenic CACNA1C/DES/MYPN mutations in a family of hypertrophic cardiomyopathy with early repolarization and short QT syndrome.
Not available
S-EPMC5399316 | biostudies-literature
ProteomicsAmyotrophic Lateral Sclerosis-associated Mutants of SOD1 Modulate miRNA Biogenesis through Aberrant Interactions with Exportin 5
Mutations in SOD1 (Superoxide Dismutase 1) gene are associated with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. By employing ascorbate peroxidase (APEX)-based proximity labeling, coupled with LC-MS/MS analysis, we uncovered 37 and 28 proteins exhibiting higher abundance i...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-01-26 | PXD035452 | Pride
Lc-ms affinity purification sod1 apex 
UnknownSupramolecular Thixotropic Ionogel Electrolyte for Sodium Batteries.
Not available
S-EPMC8953603 | biostudies-literature
UnknownNetwork Biomarkers Constructed from Gene Expression and Protein-Protein Interaction Data for Accurate Prediction of Leukemia.
Not available
S-EPMC5327377 | biostudies-literature
ProteomicsComprehensive multi-omics analysis revealed WEE1 as a synergistic lethal target with hyperthermia through CDK super-activation
The role of hyperthermic intraperitoneal chemotherapy (HIPEC) in epithelial ovarian cancer (EOC) is still controversial partly because of the poorly understood mechanism of action. Further an understanding of the underlying mechanisms could identify potential combination therapies. Here, we conduct ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-12 | PXD040849 | Pride
Wee1 Hyperthermia Multi-omics Cdk1 Ovarian cancer Azd1775 
UnknownExploring the role of circ-GALK2 in vascular smooth muscle cell calcification: mechanisms and implications.
Not available
S-EPMC12359971 | biostudies-literature
UnknownSerum response factor accelerates the high glucose-induced Epithelial-to-Mesenchymal Transition (EMT) via snail signaling in human peritoneal mesothelial cells.
Not available
S-EPMC4193747 | biostudies-literature
ProteomicsParabacteroides distasonis-Derived Outer Membrane Vesicles Enhance Antitumor Immunity in Colon Cancer by Modulating CXCL10 and CD8+ T Cells
Outer membrane vesicles of Parabacteroides distasonis
ORGANISM(S): Parabacteroides Distasonis Atcc 8503 
PXD051464 |
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