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UnknownRole of peroxisome proliferator-activated receptors gene polymorphisms in type 2 diabetes and metabolic syndrome.
Not available
S-EPMC4434087 | biostudies-literature
ProteomicsThe novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L
Here, by state-of-the-art mass spectrometry-based quantitative proteomic technology, we systematically screened the potential neo-substrates of a novel thalidomide derived cereblon modulator CC-885.
ORGANISM(S): Homo Sapiens 
2020-01-11 | PXD017071 |
ProteomicsImproving Mass Spectrometry Analysis of Protein Structures with Arginine-Selective Chemical Cross-linkers
we develop a series of arginine selective bifunctional aromatic glyoxal cross-linkers (ArGOs) and demonstrate their ability to cross-link model proteins and a protein complex. We also introduce the first arginine-lysine heterobifunctional cross-linker (KArGO), which provides significantly greater su...
ORGANISM(S): Escherichia Coli 
2019-01-14 | PXD012341 |
ProteomicsLow glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
This project identified the interacting proteins of p53 under glucose starvation in HEK293 cells.
ORGANISM(S): Homo Sapiens 
2023-04-04 | PXD041361 |
ProteomicsLithocholic acid targets TULP3-Sirtuins to deacetylate v-ATPase and activate AMPK
Lithocholic acid (LCA), accumulated in mammals during calorie restriction (CR), can activate AMP-activated protein kinase (AMPK) and slow down ageing1. However, how LCA is signalled to activate AMPK and elicit the biological effects is unclear. Here, we show that LCA can enhance the activity of sirt...
ORGANISM(S): Homo Sapiens Mus Musculus 
PXD056134 |
ProteomicsThe aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
The activity of 5’-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability of glucose. When glucose levels are low, the glycolytic enzyme aldolase is not bound to fructose-1,6-bisphosphate (FBP) and, instead, signals to activate lysosomal AMPK. ...
ORGANISM(S): Oryctolagus Cuniculus 
2022-08-10 | PXD035968 |
UnknownExtended pharmacological thromboprophylaxis and clinically relevant venous thromboembolism after major abdominal and pelvic surgery: international, prospective, propensity score-weighted cohort study.
Not available
S-EPMC11894929 | biostudies-literature
UnknownEffect of Hydroxychloroquine in Hospitalized Patients with Covid-19.
Not available
S-EPMC7556338 | biostudies-literature
UnknownDexamethasone in Hospitalized Patients with Covid-19.
Not available
S-EPMC7383595 | biostudies-literature
UnknownAzithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC7884931 | biostudies-literature
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