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ProteomicsNrf2-mediated enhancer activation via phase separation ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease
Mitochondrial dysfunction is emerging as a crucial contributor to the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD), but the molecular mechanisms underlying the disturbed mitochondrial homeostasis in cystic cells remain elusive. In the present study, we identify impaired activ...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-12 | PXD016312 | Pride
Lc-msms Mouse Kidney Adpkd 
ProteomicsNuclear condensation of CDYL links histone crotonylation and cystogenesis in autosomal dominant polycystic kidney disease
We identify the Kcr sites on histones that are targeted by CDYL in ADPKD cells (WT9-12 cells). We chose to knock out CDYL in WT 9-12 cells (CDYL KO) through CRISPR/Cas9-mediated gene editing to increase the overall levels of histone Kcr. We quantified Kcr modifications on different histone residues ...
ORGANISM(S): Homo Sapiens 
2022-01-17 | PXD031029 |
UnknownMultiomics dissection of Brassica napus L. lateral roots and endophytes interactions under phosphorus starvation.
Not available
S-EPMC11551189 | biostudies-literature
ProteomicsEffect of potato glycoside alkaloids on mitochondrial protein of Fusarium solani
Effect of Potato Glycoside Alkaloids on Mitochondria Energy Metabolism of Fusarium solani, the Root Rot Pathogen of Lycium Barbarum.
ORGANISM(S): Fusarium Solani F. Sp. Glycines 
2024-12-16 | PXD058927 |
GenomicsSCLC_SNP_6.0 - samples
SNP 6.0 arrays of small cell lung cancer
EGAD00010000558 | EGA
Genomicsena-DATASET-RTL-11-03-2015-12:07:49:303-16 - samples
Whole genome sequencing was performed with DNA extracted from fresh-frozen tumor and normal material. Short insert DNA libraries were prepared with the TruSeq DNA PCRfree sample preparation kit (Illumina) for paired-end sequencing at a minimum read length of 2x100bp. Human DNA libraries were sequenc...
EGAD00001001273 | EGA
Genomicsena-DATASET-RTL-06-02-2015-14:59:15:066-180 - samples
RNA-sequencing (RNA-seq) was performed with RNA extracted from fresh-frozen human tumor tissue samples. cDNA libraries were prepared from poly-A selected RNA applying the Illumina TruSeq protocol for mRNA. The libraries were then sequenced with a 2 x 100bp paired-end protocol to a minimum mean cover...
EGAD00001001244 | EGA
GenomicsComprehensive genomic profiles of small cell lung cancer
We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. We found bi-allelic inactivation of TP53 and RB1 in nearly all the tumors analyzed, sometimes by complex genomic rearrangements. Two tumors with wild-type RB1 had evidence of chromothripsis leadi...
EGAS00001000925 | EGA
GenomicsDAC University of Cologne
Data Access Committee EGAC00001000064
EGAC00001000064 | EGA
UnknownSelection criteria for large core trials: rationale for the ANGEL-ASPECT study design.
Not available
S-EPMC8785010 | biostudies-literature
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