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ProteomicsN-terminomics Analysis of Mouse cultured cortical neuron during excitotoxicity
Excitotoxicity is a primary pathological process directing neuronal cell death in both acute neurological disorders and neurodegenerative diseases such as ischemic stroke and Alzheimer’s disease. We use mouse cultured cortical neuron treated with 100uM of Glutamate for a model of excitotoxicity and ...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-07 | PXD040648 | Pride
N-term Excitotoxicity 
UnknownThe ataxia3 mutation in the N-terminal cytoplasmic domain of sodium channel Na(v)1.6 disrupts intracellular trafficking.
Not available
S-EPMC2679640 | biostudies-literature
ProteomicsRapid Aldosterone Effects in Mouse Kidney Distal Convoluted Tubules Cells
Kidney distal convoluted tubules (DCT) are important for regulation of urinary salt excretion. Aldosterone is known to exert long-term effects in this segment, and regulate sodium reabsorption via increasing abundance of the Na+-Cl- cotransporter (NCC) and the epithelial Na channel ENaC. Whether acu...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-24 | PXD010032 | Pride
Aldosterone Phosphoproteomics Quantification Distal convoluted tubules (dct) 
MetabolomicsProfiling aromatic amino acid metabolome in the human gut microbiota reveals Clostridioides difficile specific N-acyl amino acids

Owing to its compositional and chemical complexity, much of the gut microbiota metabolome remains poorly characterized. Aromatic amino acids (AAAs) have a history of being privileged substrates for the biosynthesis of diverse bioactive metabolites and thus represent a potentially rich source of b...

2026-07-23 | MTBLS13404 | MetaboLights
UnknownComplete mapping of substrate translocation highlights the role of LeuT N-terminal segment in regulating transport cycle.
Not available
S-EPMC4191883 | biostudies-literature
UnknownR229I substitution from oseltamivir induction in HA1 region significantly increased the fitness of a H7N9 virus bearing NA 292K.
Not available
S-EPMC467099 | biostudies-literature
ProteomicsIdentification of stably expressed reference genes for expression studies in Arabidopsis thaliana using mass spectrometry-based label-free quantification
Arabidopsis thaliana has been used regularly as a model plant in gene expression studies on transcriptional reprogramming upon pathogen infection, such as that by Pseudomonas syringae pv. tomato DC3000 (Pst DC3000), or when subjected to stress hormone treatments including jasmonic acid (JA), salicyl...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-09-05 | PXD035677 | Pride
Pathogen infection  jasmonic acid (ja)  salicylic acid (sa)  abscisic acid (aba)  expression study  label-free quantification (lfq)  rt-qpcr  reference gene 
UnknownFunctionalized N,N-Diphenylamines as Potent and Selective EPAC2 Inhibitors.
Not available
S-EPMC4867506 | biostudies-literature
MetabolomicsParabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a
Gut microbiota plays a key role in insulin resistance (IR). Here we perform a case-control study of Chinese adults (ChiCTR2200065715) and identify that Parabacteroides distasonis is inversely correlated with IR. Treatment with P. distasonis improves IR, strengthens intestinal integrity, and reduces ...
2023-11-01 | MTBLS7943 | MetaboLights
UnknownExfoliated 2D Nanosheet-Based Conjugated Polymer Composites with P-N Heterojunction Interfaces for Highly Efficient Electrocatalytic Hydrogen Evolution.
Not available
S-EPMC11423191 | biostudies-literature
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