Sort   by:  
 Page size 
ProteomicsN-terminomics Analysis of Mouse cultured cortical neuron during excitotoxicity
Excitotoxicity is a primary pathological process directing neuronal cell death in both acute neurological disorders and neurodegenerative diseases such as ischemic stroke and Alzheimer’s disease. We use mouse cultured cortical neuron treated with 100uM of Glutamate for a model of excitotoxicity and ...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-07 | PXD040648 | Pride
N-term Excitotoxicity 
ProteomicsDynamic changes in proteome and phosphoproteome following glutamate excitotoxicity in cultured primary cortical neurons
Excitotoxicity caused by over-stimulation of the ionotropic glutamate receptors is a key neuronal cell death process underpinning brain damage in acute and chronic neurological disorders such as ischaemic stroke, traumatic brain injury, and neurodegenerative diseases. Exactly how neurons die in exci...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-07 | PXD008353 | Pride
Neuron Phosphoproteome Proteome Excitotoxicity 
GenomicsMitochondrial activity tunes cellular resilience to excitotoxicity
Mitochondrial activity tunes cellular resilience to excitotoxicity
PRJNA1292848 | ENA
GenomicsKinomic analysis of excitotoxicity in primary neuronal cultures
Kinomic analysis of excitotoxicity in primary neuronal cultures
PRJNA1073411 | ENA
GenomicsCircadian clock-mediated neuronal gene expression in Aβ toxicity and excitotoxicity
Circadian clock-mediated neuronal gene expression in Aβ toxicity and excitotoxicity
PRJNA849149 | ENA
OtherMitochondrial activity tunes cellular resilience to excitotoxicity
The capsaicin receptor, TRPV1, mediates the detection of noxious chemical and thermal stimuli by nociceptors, primary sensory neurons of the pain pathway. Overactivation of TRPV1 leads to cellular damage or death through calcium entry and excitotoxicity. We have exploited this phenomenon to conduct ...
ORGANISM(S): Homo sapiens 
2025-07-25 | GSE302928 | GEO
GenomicsKCTD20 suppression mitigates excitotoxicity in tauopathy patient organoids
KCTD20 suppression mitigates excitotoxicity in tauopathy patient organoids
PRJNA1214220 | ENA
TranscriptomicsKinomic analysis of excitotoxicity in primary neuronal cultures
Glutamate excitotoxicity plays a critical role in neurodegeneration by triggering NMDA receptorhyperactivation, leading to elevated synaptic calcium levels and subsequent neuronal cell death. Tobetter understand how glutamateaffects neurons in neurological diseases, we conducted acomprehensive analy...
ORGANISM(S): Rattus norvegicus 
2024-05-28 | GSE255041 | GEO
GenomicsCharacterization of excitotoxicity induced transcriptional dysregulation
Characterization of excitotoxicity induced transcriptional dysregulation
PRJNA765638 | ENA
GenomicsNeuroprotective effect of secreted factors from glial progenitor cells in a model of glutamate excitotoxicity
Neuroprotective effect of secreted factors from glial progenitor cells in a model of glutamate excitotoxicity
PRJNA1187455 | ENA
Sort   by:  
 Page size