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TranscriptomicsTranslational and transcriptional RNA-seq of SBDS cell lines.
We investigated transcriptome and translatome of cell lines expressing the wild type or mutated (R126T) form of the SBDS protein, associated to the Swachmann-Bodian Diamond disease.
ORGANISM(S): Mus musculus 
2016-12-29 | E-MTAB-5089 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of gene expression associated to altered gene dosage of DeIF6 during eye development in Drosophila melanogaster
We investigated the transcriptome of the eye imaginal discs and retinae in wild type (GMR/+) and DeIF6 overexpressing (GMR>DeIF6) flies at the third instar larva stage and pupa 40 hours after puparium formation.
ORGANISM(S): Drosophila melanogaster 
2019-07-18 | E-MTAB-5954 | biostudies-arrayexpress
GenomicsEMseq of hiPSC, iMeLC, hPGCLC and hEGCLC of CTL08A genotype
In this work, hEGCLC have been obtained for the first time from hPGCLC in defined and feeder-free conditions. To study epigenetic changes (in terms of DNA methylation) during the transition from a pluripotent stem cell state to a germ cell identity and back again, we profiled hiPSC, iMeLC, day 6 hPG...
ORGANISM(S): Homo sapiens 
2026-02-10 | E-MTAB-15142 | biostudies-arrayexpress
TranscriptomicsLow-pass WGS of hiPSC and hEGCLC samples of CTL08A genotype
Low-pass whole genome sequencing (WGS) of one sample of human induced pluripotent stem cells (hiPSCs) derived from the CTL08A male cell line and three samples of CTL08A human embryonic germ cell-like cells (hEGCLCs) at passage 10 after hPGCLC-hEGCLC conversion.
ORGANISM(S): Homo sapiens 
2026-02-10 | E-MTAB-15528 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq of cerebral organoids investigating the role of CHD8 in cortical development
We used cerebral organoids generated from wildtype and CHD8 +/- human ES cells to study the effects of CHD8, one of the top ASD risk genes, on early cortical development. CHD8 +/- hESC were generated using the CRISPR/Cas9 system to create a deletion within the helicase domain. Cerebral organoids wer...
ORGANISM(S): Homo sapiens 
2022-02-01 | E-MTAB-9933 | biostudies-arrayexpress
TranscriptomicsscRNAseq of hiPSC, iMeLC, hPGCLC aggregates and hEGCLC of CTL08A genotype
In this work, hEGCLC have been obtained for the first time from hPGCLC in defined and feeder-free conditions. To study transcriptional changes during the transition from a pluripotent stem cell state to a germ cell identity and back again, we profiled hiPSC, iMeLC, day6 hPGCLC aggregates and hEGCLC ...
ORGANISM(S): Homo sapiens 
2026-02-10 | E-MTAB-15244 | biostudies-arrayexpress
Transcriptomicsbulk RNA-seq NOHA
Bulk RNA sequencing (bulk RNA-seq) data of the Neural Organoid Hormonal Atlas (NOHA). To investigate the impact of hormonal modulation on neurodevelopmental processes, we used neural organoids derived from two genetically validated human induced pluripotent stem cell (hiPSC) control lines (CTL08, ma...
ORGANISM(S): Homo sapiens 
2026-07-22 | E-MTAB-17185 | biostudies-arrayexpress
TranscriptomicsscRNAseq NOHA
To investigate the impact of hormonal modulation on neurodevelopmental processes, we performed single-cell RNA sequencing (ScRNA-seq) on neural organoids derived from two genetically validated human induced pluripotent stem cell (hiPSC) control lines (CTL08, male; CTL04, female). Organoids were chro...
ORGANISM(S): Homo sapiens 
2026-07-22 | E-MTAB-17184 | biostudies-arrayexpress
TranscriptomicsHuman cortical organoids. Chronic treatment with GSK3 inhibitor CHIR99021. Bulk RNAseq.
Here we used human cortical brain organoids to probe the longitudinal impact of GSK3 inhibition through multiple developmental stages. Chronic GSK3 inhibition increased the proliferation of neural progenitors and caused massive derangement of cortical tissue architecture. Cortical organoids were dif...
ORGANISM(S): Homo sapiens 
2020-06-04 | E-MTAB-8325 | biostudies-arrayexpress
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