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MetabolomicsElucidation of the epitranscriptomic RNA modification landscape of chikungunya virus

The genomes of positive-sense (+) single-stranded RNA (ssRNA) viruses are believed to be subjected to a wide range of RNA modifications. In this study, we focused on the chikungunya virus (CHIKV) as a model (+) ssRNA virus to study the landscape of viral RNA modification in infected human cells. ...

2024-06-11 | MTBLS8697 | MetaboLights
ProteomicsAltered brain pathways following Chikungunya virus infection
A kinetic analysis of host proteome modifications in the brain of CHIKV-infected mice sampled before and after the onset of clinical symptoms was performed. The combination of 2D-DIGE and iTRAQ proteomic approaches, followed by mass spectrometry protein identification, revealed 177 significantly dif...
ORGANISM(S): Mus musculus (Mouse) 
2015-07-07 | PXD000736 | Pride
Brain Pathways modified Mouse Alphavirus Chikungunya virus Infection Itraq Pathogenesis 2d-dige 
ProteomicsPathogenesis of chikungunya virus infection associated with fatal outcome
Chikungunya virus (CHIKV) is a mosquito-borne virus that causes acute, subacute, and chronic human diseases and can cause neurological complications and death. Here, we combined epidemiological, virological, histopathological, cytokine, molecular dynamics, metabolomics, proteomics, and genomic analy...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043815 | Pride
Chikungunya infection Plasma proteomics Immune response 
ProteomicsAedes aegypti Aag-2 cells proteome modulation in response to Chikungunya virus infection
Chikungunya virus (CHIKV) is a single-stranded positive RNA virus that belongs to the genus Alphavirus and is transmitted to humans by infected Aedes aegypti and Aedes albopictus bites. In humans, CHIKV can cause painful symptoms during acute and chronic stages of infection. However, the virus-vecto...
ORGANISM(S): Aedes aegypti Chikungunya virus strain S27-African prototype Insecta 
2022-06-02 | PXD033231 | Pride
Mosquito Rna helicases. Mass spectrometry Chikungunya virus Mitochondria Label-free quantification Apoptosis Protein synthesis 
TranscriptomicsGene expression profiling of wild type and CCR2-/- mice post chikungunya infection
A number of inhibitors of chemokine CCL2 and its receptor CCR2 are in development and may find application for treating a range of inflammatory conditions, including autoimmune and viral arthritides. Herein we sought to determine the effect of CCR2 deficiency on arthritis caused by an arthritogenic...
ORGANISM(S): Mus musculus 
2014-04-23 | E-GEOD-56965 | biostudies-arrayexpress
GenomicsChikungunya Virus Time Course Infection of Human Macrophages
Chikungunya Virus Time Course Infection of Human Macrophages
PRJNA755675 | ENA
ProteomicsTemporal quantitative proteomics of Chikungunya virus infected cells
To better understand the complex CHIKV-host interplay we used stable isotope labeling with amino acids in cell culture (SILAC) and LC-MS/MS to define the temporal dynamics of the cellular response to infection. Using samples harvested at 8, 10 and 12 hours post infection, over 4700 proteins were ide...
ORGANISM(S): Cercopithecidae (Old World monkeys) 
2015-03-16 | PXD001330 | Pride
Silac Chikungunya virus Quantitative proteomics Lc-msms 
MetabolomicsVirus-induced codon-specific reprogramming to favor viral RNA translation
Recent evidence indicates that codon usage bias regulates gene expression. How viruses, such as the emerging mosquito-borne Chikungunya virus (CHIKV), express their genomes at high levels despite an enrichment in rare codons remains a puzzling question. Using ribosome footprinting, here we analysed ...
2025-06-16 | MTBLS2443 | MetaboLights
TranscriptomicsInduction of a peptide with activity against a broad spectrum of pathogens in the Aedes aegypti salivary gland, following infection with dengue virus
Dengue viruses (DENV) are generally maintained in a cycle which requires horizontal transmission via their arthropod vector, Ae. Aegypti, to the vertebrate host. One important consequence of this process is the interference of these arboviruses with both invertebrate and vertebrate immune systems. W...
ORGANISM(S): Aedes aegypti 
2011-03-21 | E-GEOD-21528 | biostudies-arrayexpress
MetabolomicsN6-methyladenosine modification is not a general trait of positive-sense RNA viral genomes

Despite the nuclear localization of the m6A machinery, the genomes of multiple exclusively-cytoplasmic RNA viruses, such as chikungunya (CHIKV) and dengue (DENV), are reported to be extensively m6A-modified. However, these findings are mostly based on m6A-seq, an antibody-dependent technique with...

2024-01-25 | MTBLS6978 | MetaboLights
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