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ProteomicsCovalent Fragment Screening and Optimization Identifies Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C- terminal Hydrolase L1
Dysregulation of the ubiquitin-proteasome systems is a hallmark of various disease states including neurodegenerative diseases and cancer. Ubiquitin C-terminal Hydrolase L1 (UCHL1), a deubiquitinating enzyme, is expressed primarily in the central nervous system under normal physiological conditions,...
ORGANISM(S): Homo sapiens (Human) 
2026-10-09 | PXD045257 | Pride
Breast cancer Covalent inhibitor Deubiquitinating enzyme Chloroacetohydrazide Uchl1 Chloroacetamide Ubiquitin c-terminal hydrolase l1 Dub Probe discovery 
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