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ProteomicsProteomics in biomanufacturing control: Protein dynamics of CHO-K1 cells and conditioned media during apoptosis and necrosis
Cell viability has a critical impact on product quantity and quality during the biomanufacturing of therapeutic proteins. An advanced understanding of changes in the cellular and conditioned media proteomes upon cell stress and death is therefore needed for improved bioprocess control. Here, a high ...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2018-02-27 | PXD008297 | Pride
Proteomics Cho Keywords: biomanufacturing Necrosis Apoptosis 2d-lc-mse 
UnknownMild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells.
Not available
S-EPMC5864046 | biostudies-literature
TranscriptomicsThe gamma secretase inhibitor LLNle induces apoptosis of human GBM tumor initiating cells
Glioblastomas (GBM) are poorly differentiated astrocytic tumors arising in the Central Nervous System (CNS), which despite aggressive treatments are still characterized by a fatal outcome. Several studies have shown the existence of a subpopulation of cells within glioma tumors displaying cancer ste...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-14581 | biostudies-arrayexpress
UnknownRisk factors for transplant-associated thrombotic microangiopathy and mortality in a pediatric cohort.
Not available
S-EPMC7284101 | biostudies-literature
UnknownHeparan sulfate glycosaminoglycans are receptors sufficient to mediate the initial binding of adenovirus types 2 and 5.
Not available
S-EPMC115122 | biostudies-literature
UnknownOptimizing the Use of Gene Expression Profiling in Early-Stage Breast Cancer.
Not available
S-EPMC5455310 | biostudies-literature
ProteomicsQuantitative proteomics Reveals Targets of Protein Kinase SnRK1 in Arabidopsis under Submergence
SNF1 RELATED PROTEIN KINASE 1 (SnRK1) is proposed as a central integrator of regulatory pathways in plant stress and energy starvation signaling. We observed in this study that the Arabidopsis SnRK1.1 dominant negative mutant (SnRK1.1K48M) had lower tolerance to submergence than the wild-type, sugge...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2016-04-07 | PXD002353 | Pride
Snrk1.1 Proteomics Submergence 
TranscriptomicsTranscriptome analysis and molecular marker discovery in red pepper, Capsicum annuum L. TF68
Transcriptome from high throughput sequencing-by-synthesis is a good resource of molecular markers. In this study, we present utility of massively parallel sequencing by synthesis for profiling the transcriptome of red pepper (Capsicum annuum L. TF68) by 454 GS-FLX pyrosequencing. Through the genera...
ORGANISM(S): Capsicum annuum 
2011-09-08 | E-GEOD-29215 | biostudies-arrayexpress
ProteomicsQuantitative Phosphoproteomics Reveals Targets of Protein Kinase SnRK1 in Arabidopsis under Submergence
SNF1 RELATED PROTEIN KINASE 1 (SnRK1) is proposed as a central integrator of regulatory pathways in plant stress and energy starvation signaling. We observed in this study that the Arabidopsis SnRK1.1 dominant negative mutant (SnRK1.1K48M) had lower tolerance to submergence than the wild-type, sugge...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2016-04-07 | PXD001815 | Pride
Energy starvation Submergence Snrk1 Phosphoproteomics 
UnknownA degron system targeting endogenous PD-1 inhibits the growth of tumor cells in mice.
Not available
S-EPMC9204894 | biostudies-literature
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