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ProteomicsMolecular insights of cholestasis in MDR2KO murine liver organoids. A model for the early detection of cirrhosis and HCC
MDR3 (multidrug resistance 3) deficiency in humans (MDR2 in mice) causes progressive familial intrahepatic cholestasis type 3 (PFIC3). PFIC3 is a lethal disease characterized by an early onset of intrahepatic cholestasis, progressing to liver cirrhosis which is considered a preneoplastic condition, ...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-17 | PXD047995 | Pride
Pfic3 Mdr2 Cholestasis and hepatocellular carcinoma Organoid 
TranscriptomicsGene expression data of human hepatocellular carcinoma (HCC)
We used Affymetrix microarray profiling to analyze gene expression patterns in healthy donor liver as well as tumor and paired non-tumor tissue of HCC patients. For gene expression profiling, tumors and paired non-tumor tissues were profiled separately using a single channel array platform. Tumor an...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-14520 | biostudies-arrayexpress
TranscriptomicsLoss of p21 expression enhances DNA damage, cholestasis and hepatocarcinogenesis in the liver
Overexpression of p21 in NEMOM-NM-^Thepa animals protects against DNA damage, acceleration of hepatocarcinogenesis and cholestasis. As strengthened by our LPS stimulation experiments, we identified a novel protective role of p21 against DNA damage. Expression profiling of livers from wild type, NEMO...
ORGANISM(S): Mus musculus 
2015-03-01 | E-GEOD-61100 | biostudies-arrayexpress
GenomicsStudy of pediatric hepatocellular carcinoma caused by bile salt export pump deficiency
Hepatocellular carcinoma (HCC) is almost invariably associated with an underlying inflammatory state, whose direct contribution to the acquisition of critical genomic changes is unclear. We mapped the acquired genomic alterations in human and mouse HCCs induced by defects in hepatocyte biliary trans...
EGAS00001000749 | EGA
GenomicsStudy of pediatric hepatocellular carcinoma with BSEP deficiency
Data Access Committee EGAC00001000191
EGAC00001000191 | EGA
UnknownNewer variants of progressive familial intrahepatic cholestasis.
Not available
S-EPMC8727216 | biostudies-literature
TranscriptomicsConditional elimination of c-Met signaling in the liver aggravates oxidative stress and cholestasis, and deregulates lipid metabolism, under a high cholesterol diet
Background: Genetic elimination of c-Met signaling in the liver has been shown to impact many cellular pathways involved in repair, regeneration, lipid homeostasis and redox balance. In this study, we analyzed a nutritional model of hepatic steatosis in Met fl/fl ; Alb-Cre +/- (MetKO) mice in a 129S...
ORGANISM(S): Mus musculus 
2012-07-10 | E-GEOD-30651 | biostudies-arrayexpress
UnknownClinical and ABCB11 profiles in Korean infants with progressive familial intrahepatic cholestasis.
Not available
S-EPMC4873882 | biostudies-literature
UnknownProgressive Familial Intrahepatic Cholestasis in Korea: A Clinicopathological Study of Five Patients.
Not available
S-EPMC6639708 | biostudies-literature
UnknownDisrupting bile acid metabolism by suppressing Fxr causes hepatocellular carcinoma induced by YAP activation.
Not available
S-EPMC12000370 | biostudies-literature
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