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MetabolomicsMetabolic interactions of “catecholamine-cholesterol derivatives” as a potential mechanism for immunomodulation of chicken adipose tissue

In recent years, the immunomodulatory function of adipose tissue has attracted much attention; however, the mechanism of steady-state regulation of the immune microenvironment in adipose tissue remains unclear. Catecholamines (CAs) activate adipocyte surface β3-AR to promote lipid metabolism, and...

2025-07-15 | MTBLS12719 | MetaboLights
MetabolomicsCholesterol maintains the degradative capacity of lysosomes during clearance and recycling of dysfunctional mitochondria
Efficient clearance and recycling of dysfunctional mitochondria through the robust catabolic activity of lysosomes is essential for cellular health. However, how membrane lipids contribute to maintaining the degradative capacity of lysosomes remains poorly understood. Here, we show that cholesterol ...
2026-07-30 | MTBLS15181 | MetaboLights
TranscriptomicsIncrease in membrane cholesterol of neurons in culture recapitulates AlzheimerM-bM-^@M-^Ys disease early phenotypes.
Levels of membrane-associated cholesterol were shown to be increased in the brain of individuals with sporadic AlzheimerM-bM-^@M-^Ys disease (AD) and correlated with the severity of the disease. We previously found that heavy membrane cholesterol burden promotes amyloid precursor protein (APP) endoc...
ORGANISM(S): Rattus norvegicus 
2015-01-15 | E-GEOD-46221 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of ApoE3Leiden mice exposed to varying doses of cholesterol to examine the effects of dietary cholesterol on liver homeostasis in the context of early atherosclerotic lesion development
A dose-response study of the effects of dietary cholesterol on liver homeostasis in the context of early atherosclerotic lesion development using ApoE3Leiden mice
ORGANISM(S): Mus musculus 
2007-10-13 | E-TABM-253 | biostudies-arrayexpress
MetabolomicsAmphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism, lipid transport and oxidative stress response

Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen independent lines of Leishmania mexicana and one L. infantum line were selected for resistance to either amphotericin B or the related polyene antimicrobial, nystatin. Sterol profiling revealed tha...

2022-09-22 | MTBLS2744 | MetaboLights
Proteomics: GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics through ER-Mitochondria cholesterol transport
During autophagy, cytosolic cargo is sequestered into double-membrane vesicles called autophagosomes. The origin and identity of the membranes that form the autophagosome remain to be fully characterized. Here, we investigated the role of cholesterol in starvation-induced autophagy and identify a ro...
ORGANISM(S): Homo sapiens (Human) 
2022-10-19 | PXD027502 | Pride
Er-mitochondria Autophagy Ms Cholesterol transport 
GenomicsHepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis
Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis
PRJNA849943 | ENA
ProteomicsApoA-I [human] (CSL112) infusion increases LCAT levels in HDL particles and promotes reverse cholesterol transport
Background: High-density lipoprotein (HDL)-cholesterol is inversely correlated with cardiovascular risk, but increasing its circulating concentration is insufficient to prevent adverse cardiovascular outcomes. Instead, the emerging paradigm is on increasing the function of HDL and its major protein...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD057196 | Pride
Lecithin-cholesterol acyl transferase Proteome Csl112 High-density lipoprotein Acute myocardial infarction 
ModelsMorgan2016 - Dynamics of cholesterol metabolism and ageing
Morgan2016 - Dynamics of cholesterol metabolism and ageing This model is described in the article: Mathematically modelling the dynamics of cholesterol metabolism and ageing. Morgan AE, Mooney KM, Wilkinson SJ, Pickles NA, Mc Auley MT. BioSystems 2016 Jul; 145: 19-32 Abstrac...
2017-06-01 | MODEL1508170000 | BioModels
GenomicsRegulation of cellular cholesterol distribution via non-vesicular lipid transport at ER-Golgi contact sites
Regulation of cellular cholesterol distribution via non-vesicular lipid transport at ER-Golgi contact sites
PRJNA1005938 | ENA
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