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MetabolomicsInulin gel-mediated delivery of Clostridium butyricum spores protects against acute kidney injury via regulation of ER-mitochondria contacts
Acute kidney injury (AKI) progression is closely associated with gut microbiota dysbiosis. However, the detailed mechanism remains unclear. In this study, we found that patients with AKI had decreased beneficial bacteria and reduced butyric acid levels in the intestine. Furthermore, butyrate allevia...
2026-09-17 | MTBLS15607 | MetaboLights
MetabolomicsReduced ER-mitochondria connectivity promotes neuroblastoma multidrug resistance
Not available
ORGANISM(S): Homo sapiens 
ST002054 | MetabolomicsWorkbench
MetabolomicsPhospholipid transfer function of PTPIP51 at mitochondria-associated ER membranes
Not available
ORGANISM(S): Homo sapiens 
ST001717 | MetabolomicsWorkbench
ProteomicsProteomic Analysis of Retinal Mitochondria-associated ER Membranes Identified Novel Proteins of Retinal Degeneration in Long-term Diabetes
The mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) is the physical contact site between the ER and the mitochondria and plays a vital role in the regulation of calcium trafficking and bioenergetics. Previous studies suggest that disturbances in calcium trafficking and dysregulatio...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-10-15 | PXD033040 | Pride
Diabetic retinopathy  type 1 diabetes  mitochondria-associated er membrane  proteomic  retinal degeneration 
ProteomicsThe ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria
Most mitochondrial proteins are synthesized on cytosolic ribosomes and imported into mitochondria in a post-translational reaction. Mitochondrial precursor proteins which use the ER-SURF pathway employ the surface of the endoplasmic reticulum (ER) as an important sorting platform. How they reach the...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-05 | PXD044379 | Pride
Contact sites. endoplasmic reticulum. ermes. er-surf. protein import. protein targeting. mitochondria 
ProteomicsThe ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria - Data Set 1
Most mitochondrial proteins are synthesized on cytosolic ribosomes and imported into mitochondria in a post-translational reaction. Mitochondrial precursor proteins which use the ER-SURF pathway employ the surface of the endoplasmic reticulum (ER) as an important sorting platform. How they reach the...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-05 | PXD044362 | Pride
Yeast membrane contact sites ermes. er-surf. protein import. protein targeting. mitochondria 
ProteomicsThe ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria - Data Set 2
Most mitochondrial proteins are synthesized on cytosolic ribosomes and imported into mitochondria in a post-translational reaction. Mitochondrial precursor proteins which use the ER-SURF pathway employ the surface of the endoplasmic reticulum (ER) as an important sorting platform. How they reach the...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-05 | PXD044368 | Pride
Contact sites. endoplasmic reticulum. ermes. er-surf. protein import. protein targeting. mitochondria 
Proteomics: GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics through ER-Mitochondria cholesterol transport
During autophagy, cytosolic cargo is sequestered into double-membrane vesicles called autophagosomes. The origin and identity of the membranes that form the autophagosome remain to be fully characterized. Here, we investigated the role of cholesterol in starvation-induced autophagy and identify a ro...
ORGANISM(S): Homo sapiens (Human) 
2022-10-19 | PXD027502 | Pride
Er-mitochondria Autophagy Ms Cholesterol transport 
UnknownThe ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria.
Not available
S-EPMC11014988 | biostudies-literature
ProteomicsRevisiting the relevance of the accumulation of apolipoprotein E (APOE) in mitochondria-associated ER membranes: Investi-gation of hepatic protein-protein interactions of APOE with LONP1, TOMM40 and VDAC1
Investigating the subcellular distribution and protein interaction of APOE and the modulation by cellular stress signals, we aimed to contribute to the elucidation of putative novel functions. We identified APOE as hepatic mitochondria-associated ER-membranes (MAM) protein, where it most likely inte...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055281 | Pride
Mitochondria-er contacts (merc) Mam Stress response Proteome analysis Subcellular distribution Liver Apoe4 
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