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ProteomicsRegulation of mitophagy by Fis1 and Fascin1-organized actin
Mitophagy, the autophagic degradation of mitochondria, plays a central role in controlling the quality and quantity of mitochondria, thereby ensuring cellular health. The mitochondrial outer membrane protein Fis1 is important for several types of mitophagy, but its mechanism of action remains unclea...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-07 | PXD062948 | Pride
Mitophagy Fascin1 Fis1 Mitochondria Actin filaments 
ProteomicsNMS-873 leads to dysfunctional glycometabolism in a p97-independent manner
ATP-competitive p97 inhibitor CB-5339, the successor of CB-5083, is being evaluated in Phase 1 clinical trials for anti-cancer therapy. Different modes of action p97 inhibitors such as allosteric inhibitors are useful to overcome one the major problems of targeted therapy: drug-induced resistance. W...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD025898 | Pride
Protein stability Proteomics Resistance P97 inhibitor Glycometabolism 
ProteomicsSkeletal muscle cell protein dysregulation highlights the pathogenesis mechanism of myopathy-associated p97/VCP R155H mutations
p97/VCP, a hexametric member of the AAA-ATPase superfamily, has been associated with a wide range of cellular protein pathways, such as proteasomal degradation, the unfolding of polyubiquitinated proteins, and autophagosome maturation. Autosomal dominant p97/VCP mutations cause a rare hereditary mul...
ORGANISM(S): Homo sapiens (Human) 
2023-07-23 | PXD044004 | Pride
Ibmpfd/als Myopathy Ipscs R155h mutation. Vcp/p97 Skeletal muscle 
UnknownNMS-873 Leads to Dysfunctional Glycometabolism in A p97-Independent Manner in HCT116 Colon Cancer Cells.
Not available
S-EPMC9024726 | biostudies-literature
UnknownAllosteric p97 Inhibitors Can Overcome Resistance to ATP-Competitive p97 Inhibitors for Potential Anticancer Therapy.
Not available
S-EPMC9049325 | biostudies-literature
UnknownSpecific mutations in the D1-D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors.
Not available
S-EPMC5672561 | biostudies-literature
UnknownThe Globular C1q Receptor Is Required for Epidermal Growth Factor Receptor Signaling during Candida albicans Infection.
Not available
S-EPMC8561387 | biostudies-literature
UnknownN-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma.
Not available
S-EPMC11270646 | biostudies-literature
UnknownTumor-suppressive miR148a is silenced by CpG island hypermethylation in IDH1-mutant gliomas.
Not available
S-EPMC4233178 | biostudies-literature
UnknownIntermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs.
Not available
S-EPMC9132770 | biostudies-literature
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