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MetabolomicsUntargeted metabolomic analysis in cats with naturally occurring inflammatory bowel disease and alimentary small cell lymphoma
Feline chronic enteropathy (CE) is a common gastrointestinal disorder in cats and mainly comprises inflammatory bowel disease (IBD) and small cell lymphoma (SCL). Differentiation between IBD and SCL can be diagnostically challenging. We characterized the fecal metabolome of 14 healthy cats and 22 ca...
2021-07-13 | MTBLS440 | MetaboLights
ProteomicsqXL-MS of insulin resistance in mouse skeletal muscle
We established a whole tissue qXL-MS workflow to investigate proteome-wide changes in protein:protein interactions in mouse skeletal muscle insulin resistance (IR). Mice were feed a standard chow diet or a high fat diet (HFD) for 12 weeks which induced skeletal muscle insulin resistance. The Extenso...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-29 | PXD077541 | Pride
Mouse skeletal muscle Insulin resistance 
ProteomicsProteomic and phosphoproteomic analysis of PKCe KO
Activation of protein kinase C epsilon (PKCε) in the liver has been widely associated with hepatic insulin resistance. PKCε is proposed to inhibit insulin signalling through phosphorylation of the insulin receptor. We have tested this directly by breeding PKCε floxed mice with mice expressing Cre re...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-04 | PXD010212 | Pride
Adipocyte Pkcepsilon 
ProteomicsProteomic analysis of the mouse tongue proteome in response to western diet
The tongue is a heavily innervated and vascularized striated muscle that plays an important role in vocalization and swallowing. The surface of the tongue is lined with papillae which contain gustatory cells expressing various taste receptors. There is growing evidence to suggest our perceptions of ...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD025190 | Pride
Metabolism Proteomics Obesity Tongue Taste 
ProteomicsPhosphoproteomics and proteomics of insulin signaling in aged mouse bone
We compared the in vivo insulin signaling response in bone tissue of 10- verses 73-week old C57BL/6J male mice (Figure 1A). Saline or insulin (2.5 mU/kg) was interperitoneally injected and mice sacrificed after 20 min. Tibia bone was rapidly dissected and flushed with ice-cold PBS within 30 sec to r...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-16 | PXD054205 | Pride
Insulin signaling Bone Phosphoproteomics 
MetabolomicsX chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction

Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. Here we find that impaired glucose homeostasis and muscle weakness in statin-treated f...

2024-05-23 | MTBLS9677 | MetaboLights
ProteomicsMapping the complexity of ME/CFS: Evidence for abnormal energy metabolism, altered immune profile and vascular dysfunction
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disorder with no known underlying mechanisms, diagnostic tools, or treatments. Multiple areas of dysfunction have been extensively studied, but rarely examined together. We recruited age- and sex-matched ME/CFS patients and he...
ORGANISM(S): Homo sapiens (Human) 
2025-11-14 | PXD068504 | Pride
Metabolomics Immune dysfunction Energy metabolism Myalgic encephalomyelitis/chronic fatigue syndrome 
GenomicsGenetic Variation Determines PPARγ Function and Antidiabetic Drug Response In Vivo [ChIP-seq]
SNPs affecting disease risk often reside in non-coding genomic regions. Here we show that SNPs are highly enriched at mouse strain-selective adipose tissue binding sites for PPARγ, a nuclear receptor for antidiabetic drugs. Many such SNPs alter binding motifs for PPARγ or cooperating factors, and fu...
ORGANISM(S): Homo sapiens 
2015-07-02 | E-GEOD-64458 | biostudies-arrayexpress
MetabolomicsNicotinamide Riboside is Uniquely Bioavailable in People and Mice
Nicotinamide riboside (NR) is in wide use as an NAD+ precursor vitamin. Here we conducted experiments to determine the time and dose-dependent effects of NR on blood, liver and heart NAD+ metabolism in people and mice. We report that human blood cell NAD+ can rise as much as 2.7-fold with a single d...
2016-09-09 | MTBLS368 | MetaboLights
TranscriptomicsEffect of EglN1 knockdown on smooth muscle expression
Ischemic preconditioning is the phenomenon whereby brief periods of sublethal ischemia protect against a subsequent, more prolonged, ischemic insult. In remote ischemic preconditioning (RIPC), ischemia to one organ protects other organs at a distance. We developed mouse models to ask if inhibition o...
ORGANISM(S): Mus musculus 
2016-02-11 | E-GEOD-77789 | biostudies-arrayexpress
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