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ProteomicsRapid and Deep Proteomes by Faster Sequencing on a Benchtop Quadrupole Ultra-High-Field Orbitrap Mass Spectrometer
The faster sequencing speed available on the latest Q Exactive HF mass spectrometer is investigated and evaluated by four different acquisition methods and benchmarked across three generations of Q Exactive instruments. Also the instrument capabilities for offline high pH reversed-phase peptide frac...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-01 | MSV000079548 | MassIVE
ProteomicsBiomineralization of Mantis Shrimp Dactyl Club during Development: Apatite Formation and Brominated Organic Components
The stomatopod Odontodactylus scyllarus uses weaponized clubs like appendages to attack its prey. These clubs are made of apatite, chitin, amorphous calcium carbonate, and amorphous calcium phosphate ordered in a highly hierarchical structure with multiple regions and layers. We follow the developme...
ORGANISM(S): Cellular Organisms 
2023-10-05 | PXD037177 | JPOST Repository
OtherRapid and Deep Proteomes by Faster Sequencing on a Benchtop Quadrupole Ultra-High-Field Orbitrap Mass Spectrometer.
Data from ProteomeXchange, PXD ID: PXD001305. Experiment: UPLC9_RJC_DEV_HeLa_03, file: 20140418_QE7_UPLC9_RJC_DEV_HeLaFrac10_03.mzml. Published as part of J Proteome Res. 2014 Oct 28 . From the Abstract: {{i}} Here, we investigate faster sequencing speed of the latest Q Exactive HF mass spectromete...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM11210030961 | GPMDB
Resource Reanalysis 
OtherRapid and Deep Proteomes by Faster Sequencing on a Benchtop Quadrupole Ultra-High-Field Orbitrap Mass Spectrometer.
Data from ProteomeXchange, PXD ID: PXD001305. Experiment: UPLC9_RJC_DEV_HeLa_02, file: 20140418_QE7_UPLC9_RJC_DEV_HeLaFrac1_02.mzml. Published as part of J Proteome Res. 2014 Oct 28 . From the Abstract: {{i}} Here, we investigate faster sequencing speed of the latest Q Exactive HF mass spectrometer...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32320004807 | GPMDB
Resource Reanalysis 
ProteomicsRNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I
RIG-I like helicases (RLHs) and cGAS are crucial cytosolic sensors of viral RNA and DNA, respectively, and induce type I IFNs via TBK1/IKKε. hnRNPM was described to possess antimicrobial activities. Here, we show that hnRNPM promotes IRF3 phosphorylation and type I IFN induction downstream of cGAS a...
ORGANISM(S): Homo sapiens (Human) 
2024-11-11 | PXD028160 | Pride
Ap-ms Lc-ms/ms 
TranscriptomicsOverexpression of Integrin α11 Induces Cardiac Fibrosis in Mice
The integrin α11-overexpressing transgenic mouse strain was generated to further understand the function of α11, after generation of our integrin α11-KO strain. Analysis of the strain showed that integrin α11 was highly expressed in heart, which correlated with a fibrotic heart phenotype. To und...
ORGANISM(S): Mus musculus 
2017-08-31 | E-MTAB-5040 | biostudies-arrayexpress
ProteomicsRecombinant dimeric PICK1 protein inhibitors for long-term relief of chronic pain by AAV therapeutics
Chronic neuropathic pain’s impact, persistence, and limited treatments render it relevant for gene therapy. Here, we describe the development and application of self-assembling dimeric peptide inhibitors of the pain-associated scaffolding protein PICK1 (protein interacting with C-kinase 1) delivered...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-10 | PXD074049 | Pride
Pick1  protein interacting with c-kinase 1  neuropathic pain Pain treatment  neuropathic pain treatment  gene therapy  aav therapeutics. 
ProteomicsRecombinant dimeric PICK1 protein inhibitors for long-term relief of chronic pain by AAV therapeutics
Chronic neuropathic pain’s impact, persistence, and limited treatments render it relevant for gene therapy. Here, we describe the development and application of self-assembling dimeric peptide inhibitors of the pain-associated scaffolding protein PICK1 (protein interacting with C-kinase 1) delivered...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-10 | PXD073925 | Pride
Pick1  protein interacting with c-kinase 1  neuropathic pain Pain treatment  neuropathic pain treatment  gene therapy  aav therapeutics 
UnknownRNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I
Not available
S-SCDT-10_1038-S44318-024-00331-X | biostudies-other
UnknownHealth Status Outcomes With Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting in ISCHEMIA.
Not available
S-EPMC12492304 | biostudies-literature
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