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TranscriptomicsDNA methylation distinguishes pathologically normal human tissues
Epigenetic control of gene transcription is critical for normal human development and cellular differentiation. While alterations of epigenetic marks such as DNA methylation have been linked to cancers and many other human diseases, interindividual epigenetic variation in normal tissues due to aging...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-19434 | biostudies-arrayexpress
TranscriptomicsBreast tumor DNA methylation
Using primary breast tumors from 162 women from the Kaiser Division of Research Pathways Study and the Illumina GoldenGate methylation bead-array platform, we measured CpG loci associated with cancer-related genes 162 tumor specimens from the initial diagnostic biopsy were obtained from the KPNC tum...
ORGANISM(S): Homo sapiens 
2010-07-28 | E-GEOD-22290 | biostudies-arrayexpress
TranscriptomicsIntegrated profiling reveals a global correlation between epigenetic and genetic alterations in mesothelioma
This SuperSeries is composed of the following subset Series: GSE20989: Mesothelioma integrative genomics: DNA methylation GSE21057: Copy number alterations in pleural mesothelioma Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-21058 | biostudies-arrayexpress
TranscriptomicsmiRNA expression in head and neck squamous cell carcinoma (HNSCC)
The involvement of microRNAs (miRNAs) in cancer and their potential as biomarkers of diagnosis, prognosis and response to therapy is becoming increasingly appreciated. The etiology of head and neck squamous cell carcinoma (HNSCC) is predominantly associated with the synergistic effects of tobacco an...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-11163 | biostudies-arrayexpress
TranscriptomicsMesothelioma integrative genomics: DNA methylation
Integrated profiling of somatic molecular alterations present in tumors is necessary to further our understanding of the tumorigenic process. We investigated the potential relationships between gene copy number alterations and DNA methylation profiles in a case series of pleural mesotheliomas (n=23)...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-20989 | biostudies-arrayexpress
TranscriptomicsCopy number alterations in pleural mesothelioma
Integrated profiling of somatic molecular alterations present in tumors is necessary to further our understanding of the tumorigenic process. We investigated the potential relationships between gene copy number alterations and DNA methylation profiles in a case series of pleural mesotheliomas (n=23)...
ORGANISM(S): Homo sapiens 
2010-07-31 | E-GEOD-21057 | biostudies-arrayexpress
TranscriptomicsNon-small-cell lung tumor and normal lung tissue methylation
Using paired tumor and non-tumor lung tissues from 47 individuals we identified common changes in DNA methylation associated with the development of non-small cell lung cancer. Pathologically normal lung tissue taken at the time of cancer resection was matched to tumorous lung tissue and together we...
ORGANISM(S): Homo sapiens 
2012-07-02 | E-GEOD-27902 | biostudies-arrayexpress
TranscriptomicsLung adenocarcinoma and mesothelioma DNA methylation
Pathologic differentiation of tissue of origin in tumors found in the lung can be challenging, with differentiation of mesothelioma and lung adenocarcinoma emblematic of this problem. Indeed, proper classification is essential for determination of treatment regimen for these diseases, making accurat...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-16559 | biostudies-arrayexpress
TranscriptomicsIDH1 mutation defines methylation class and survival in human glioma
Astrocytoma, oligodendroglioma, oligoastrocytoma, and ependymoma are the main histologic subtypes of glioma. The molecular character of these subtypes has profound implications for understanding their causes and treatment. We describe the epigenetic landscape of these tumor types using novel DNA met...
ORGANISM(S): Homo sapiens 
2010-12-20 | E-GEOD-20395 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis
Ductal carcinoma in situ (DCIS) of the breast is a precursor of invasive breast carcinoma (IBC). DNA methylation alterations are thought to be an early event in progression of cancer, and may prove valuable as a tool in clinical decision making and for understanding neoplastic development. Genome-wi...
ORGANISM(S): Homo sapiens 
2014-08-08 | E-GEOD-60185 | biostudies-arrayexpress
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